The effect of E-5842, a σ receptor ligand and potential atypical antipsychotic, on Fos expression in rat forebrain

We examined the ability of E-5842 (4-(4-fluorophenil)-1,2,3,6- tetrahydro-1-[4-(1,2,4-triazol-1-il)butyl] pyridine citrate), a σ receptor ligand, to increase Fos protein expression in regions of rat forebrain. An acute administration of E-5842 increased levels of Fos in the medial prefrontal cortex...

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Bibliographic Details
Published in:European journal of pharmacology 1998-12, Vol.363 (2), p.127-130
Main Authors: Guitart, Xavier, Farré, Antoni J.
Format: Article
Language:English
Subjects:
Animals
Antipsychotic Agents - pharmacology
Antipsychotic, atypical
Biological and medical sciences
Blotting, Western
Clozapine - pharmacology
Cortex, prefrontal
Fos regulation
Gene Expression - drug effects
Haloperidol - pharmacology
Immediate-early gene
Ligands
Male
Medical sciences
Neuropharmacology
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Oncogene Proteins v-fos - biosynthesis
Pharmacology. Drug treatments
Prefrontal Cortex - drug effects
Prefrontal Cortex - metabolism
Prosencephalon - drug effects
Prosencephalon - metabolism
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Pyridines - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, sigma - drug effects
Receptors, sigma - metabolism
Schizophrenia
Triazoles - pharmacology
σ Receptor
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Summary:We examined the ability of E-5842 (4-(4-fluorophenil)-1,2,3,6- tetrahydro-1-[4-(1,2,4-triazol-1-il)butyl] pyridine citrate), a σ receptor ligand, to increase Fos protein expression in regions of rat forebrain. An acute administration of E-5842 increased levels of Fos in the medial prefrontal cortex and the nucleus accumbens, without affecting the levels of the protein in the striatum, an effect very similar to that of clozapine. Our results suggest that E-5842 may be an atypical antipsychotic with low propensity to produce extrapyramidal side-effects.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(98)00812-7