Platelet activating factor-acetylhydrolase (PAF-AH) activity and HDL levels, but not PAF-AH gene polymorphisms, are associated with successful aging in Sicilian octogenarians

Background and aims : Aging is associated with an increased risk of developing atherosclerosis. Subjects over 80 years of age without cardiovascular disease provide a model to investigate the protective factors increasing their resistance to atherosclerotic disease. Platelet-activating factor acetyl...

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Bibliographic Details
Published in:Aging clinical and experimental research 2008-04, Vol.20 (2), p.171-177
Main Authors: Campo, Salvatore, Sardo, Maria Adriana, Trimarchi, Giuseppe, Bonaiuto, Antonio, Saitta, Carlo, Bitto, Alessandra, Castaldo, Maria, Cinquegrani, Maurizio, Bonaiuto, Michele, Cristadoro, Simona, Saitta, Antonino
Format: Article
Language:English
Subjects:
1-Alkyl-2-acetylglycerophosphocholine Esterase - blood
1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics
Adult
Age Factors
Aged
Aged, 80 and over
Aging
Aging - blood
Aging - genetics
Amino Acid Substitution
Atherosclerosis - blood
Atherosclerosis - enzymology
Atherosclerosis - genetics
Base Sequence
Cardiovascular Diseases - blood
Cardiovascular Diseases - enzymology
Cardiovascular Diseases - genetics
Cholesterol, HDL - blood
DNA Primers - genetics
Female
Geriatrics/Gerontology
Humans
Italy
Lipoproteins, HDL - blood
Male
Medicine
Medicine & Public Health
Original Article
Polymorphism, Single Nucleotide
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Summary:Background and aims : Aging is associated with an increased risk of developing atherosclerosis. Subjects over 80 years of age without cardiovascular disease provide a model to investigate the protective factors increasing their resistance to atherosclerotic disease. Platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme associated with low density lipoprotein (LDL) and high density lipoprotein (HDL) inactivating platelet-activating factor (PAF) and preventing LDL oxidation by hydrolysis of oxidized phospholipids. The aim of the present study was to evaluate the contribution of the PAF-AH gene Arg92His, Ile198Thr and Ala379Val polymorphisms to resistance toward developing cardiovascular events in healthy Sicilian octogenarians. Methods: Distribution of PAF-AH genotypes and activity, and biochemical parameters, were compared between 100 octogenarians and 200 healthy adults. Results : The individuals in the elderly group displayed significantly higher levels of HDL-C (p
ISSN:1594-0667
1720-8319
DOI:10.1007/BF03324764