The reactive oxygen-driven tumor: relevance to melanoma

Summary In melanoma, at least four major signaling abnormalities have been described. They include β‐catenin deregulation (mutation/mislocalization), p16 loss, MAP kinase activation, and Akt activation. In this review, we discuss the role of the fourth pathway, known as the reactive oxygen driven tu...

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Bibliographic Details
Published in:Pigment cell and melanoma research 2008-04, Vol.21 (2), p.117-122
Main Authors: Fried, Levi, Arbiser, Jack L.
Format: Article
Language:English
Subjects:
Akt
Humans
MAP kinase
melanoma
Melanoma - classification
Melanoma - genetics
Melanoma - physiopathology
Mitogen-Activated Protein Kinases - metabolism
NK-κB
Proto-Oncogene Proteins c-akt - metabolism
reactive oxygen
Reactive Oxygen Species - metabolism
Signal Transduction - genetics
superoxide
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Summary:Summary In melanoma, at least four major signaling abnormalities have been described. They include β‐catenin deregulation (mutation/mislocalization), p16 loss, MAP kinase activation, and Akt activation. In this review, we discuss the role of the fourth pathway, known as the reactive oxygen driven tumor. The role of reactive oxygen in tumorigenesis is likely to relate to virtually all forms of cancer, and lends itself to specific therapies. These include blockade of reactive oxygen, resulting in decreased activation of NF‐κB, which should sensitize tumors to chemotherapy and radiation. The phenotype of the reactive oxygen driven tumor can be monitored using available markers already in use in most hospital laboratories.
ISSN:1755-1471
1755-148X
DOI:10.1111/j.1755-148X.2008.00451.x