Increasing drug solubility by means of bile salt–phosphatidylcholine-based mixed micelles

Study of the solubilization of commercial grades of soya phosphatidylcholine (SPC) with different purities by bile salts (BS) indicated that only highly pure grades of SPC are suitable for the preparation of clear solutions of BS/SPC-mixed micelles (BS/SPC-MM). The solubilizing capacity of different...

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Bibliographic Details
Published in:European journal of pharmaceutics and biopharmaceutics 1998-11, Vol.46 (3), p.361-367
Main Authors: Hammad, M.A, Müller, B.W
Format: Article
Language:English
Subjects:
Benzodiazepines
Benzyl alcohol
Benzyl Alcohol - chemistry
Bile Acids and Salts - chemistry
Bile salt–phosphatidylcholine-mixed micelles
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Drug Carriers
Drug Stability
General pharmacology
Medical sciences
Micelles
NMR study
Nuclear Magnetic Resonance, Biomolecular
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phosphatidylcholines - chemistry
Solubility
Solubilization
Steroidal drugs
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Summary:Study of the solubilization of commercial grades of soya phosphatidylcholine (SPC) with different purities by bile salts (BS) indicated that only highly pure grades of SPC are suitable for the preparation of clear solutions of BS/SPC-mixed micelles (BS/SPC-MM). The solubilizing capacity of different BS towards SPC increased in the following order; Sodium cholate (SC)
ISSN:0939-6411
1873-3441
DOI:10.1016/S0939-6411(98)00037-X