Immunohistochemical expression of c-erbB-2 oncoprotein and EGF-R in pre- and postmenopausal breast cancer

Tissues from 40 cases each of premenopausal and postmenopausal breast cancer were studied immunohistochemically for epidermal growth factor receptor (EGF‐R) and c‐erbB‐2 oncoprotein. In the premenopausal group, immunopositivity for c‐erbB‐2 was 15% and for EGF‐R 22.5%, whereas in the postmenopausal...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 1998-11, Vol.106 (7-12), p.1075-1080
Main Authors: RATNAKAR, NITESH, SHARMA, BHUVNESH KUMAR, CHATURVEDI, K. UMA, KAUR, SUDERSHAN, NAIK, S. L. DAYALU, RAY, AMITABHA
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor
breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - physiopathology
c-erbB-2
EGF-R
Female
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Mammary gland diseases
Medical sciences
Middle Aged
Postmenopause
Premenopause
Receptor, Epidermal Growth Factor - biosynthesis
Receptor, ErbB-2 - biosynthesis
Tumors
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Summary:Tissues from 40 cases each of premenopausal and postmenopausal breast cancer were studied immunohistochemically for epidermal growth factor receptor (EGF‐R) and c‐erbB‐2 oncoprotein. In the premenopausal group, immunopositivity for c‐erbB‐2 was 15% and for EGF‐R 22.5%, whereas in the postmenopausal group, 45% of cases were positive for c‐erbB‐2 and 42.5% for EGF‐R. The difference in immunoexpression of c‐erbB‐2 between the two groups was significant. A significant correlation was observed between the concomitant expression of c‐erbB‐2 as well as EGF‐R and lymph node involvement. Furthermore, an association was found between c‐erbB‐2 positivity and histological grading of the tumour. It is interesting that the pattern of the investigated parameters indicates the difference in the pathological events of pre‐ and postmenopausal breast cancer.
ISSN:0903-4641
1600-0463
DOI:10.1111/j.1699-0463.1998.tb00261.x