Hierridin B and 2,4-dimethoxy-6-heptadecyl-phenol, secondary metabolites from the cyanobacterium Phormidium ectocarpi with antiplasmodial activity

Bioassay guided fractionation of the lipophilic extract of the marine cyanobacterium Phormidium ectocarpi yielded a new natural product hierridin B and the previously described compound 2,4-dimethoxy-6-heptadecyl-phenol. Both structures were secured by extensive spectroscopic analysis (1D and 2D NMR...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 1998-12, Vol.49 (8), p.2383-2386
Main Authors: Papendorf, Olaf, König, Gabriele M, Wright, Anthony D
Format: Article
Language:English
Subjects:
Alkanes - chemistry
Alkanes - isolation & purification
Alkanes - pharmacology
Anisoles - chemistry
Anisoles - isolation & purification
Anisoles - pharmacology
antimalaria
antimalarial properties
Antimalarials - isolation & purification
Antimalarials - pharmacology
aromatic lipids
bioassays
biological activity
Biological and medical sciences
chemical composition
chemical structure
Cyanobacteria
Cyanobacteria - chemistry
fractionation
General pharmacology
Marine
Medical sciences
Molecular Structure
nuclear magnetic resonance spectroscopy
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenol - chemistry
Phenol - isolation & purification
Phenol - pharmacology
phenolic compounds
Phormidium
Phormidium ectocarpi
Plasmodium falciparum
proteins
secondary metabolites
spectral analysis
Spectrum Analysis
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Summary:Bioassay guided fractionation of the lipophilic extract of the marine cyanobacterium Phormidium ectocarpi yielded a new natural product hierridin B and the previously described compound 2,4-dimethoxy-6-heptadecyl-phenol. Both structures were secured by extensive spectroscopic analysis (1D and 2D NMR, MS, GC-MS, IR). The isolate (mixture) showed antiplasmodial activity towards Plasmodium falciparum.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(98)00440-3