Efficient Synthesis of 2-(Trifluoromethyl)nicotinic Acid Derivatives from Simple Fluorinated Precursors

Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trif...

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Bibliographic Details
Published in:Organic letters 2008-05, Vol.10 (9), p.1835-1837
Main Authors: Kiss, László E, Ferreira, Humberto S, Learmonth, David A
Format: Article
Language:English
Subjects:
Nicotinic Acids - chemical synthesis
Nicotinic Acids - chemistry
Nitriles - chemistry
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Summary:Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trifluoromethyl)pyridine 1-oxide.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800458k