Effect of mercury(II) on Nrf2, thioredoxin reductase-1 and thioredoxin-1 in human monocytes

Abstract Objectives Human blood levels of mercury are commonly 10 nM, but may transiently reach 50–75 nM after dental amalgam placement or removal. Controversy persists about the use of mercury because the effects of these ‘trace’ levels of mercury are not clear. Concentrations of mercury ≥5000 nM u...

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Bibliographic Details
Published in:Dental materials 2008-06, Vol.24 (6), p.765-772
Main Authors: Wataha, John C, Lewis, Jill B, McCloud, Veronica V, Shaw, Melissa, Omata, Yo, Lockwood, Petra E, Messer, Regina L.W, Hansen, Jason M
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Advanced Basic Science
Antioxidants - pharmacology
Biocompatibility
Cells, Cultured
Cytotoxicity
Dental amalgam
Dental Materials - pharmacology
Dentistry
Electrophoresis
Enzyme Inhibitors - pharmacology
Free Radical Scavengers - pharmacology
Hg(II)
Humans
Immunoblotting
Lipopolysaccharides - pharmacology
Materials Testing
Mercury
Mercury - pharmacology
Monocytes - drug effects
Monocytes - enzymology
Monocytes - metabolism
NF-E2-Related Factor 2 - drug effects
Nrf2
Oxidation-Reduction
Redox balance
Selenium Compounds - pharmacology
Thioredoxin Reductase 1 - antagonists & inhibitors
Thioredoxin Reductase 1 - drug effects
Thioredoxin reductase-1
Thioredoxin-1
Thioredoxins - drug effects
Trx1
TrxR1
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Summary:Abstract Objectives Human blood levels of mercury are commonly 10 nM, but may transiently reach 50–75 nM after dental amalgam placement or removal. Controversy persists about the use of mercury because the effects of these ‘trace’ levels of mercury are not clear. Concentrations of mercury ≥5000 nM unequivocally alter redox balance in blood cells including monocytes. In the current study, we tested a hypothesis that concentrations of mercury
ISSN:0109-5641
1879-0097
DOI:10.1016/j.dental.2007.09.002