Beneficial effect of anti-interleukin-4 antibody when administered in a murine model of tuberculosis infection

Summary There remains much controversy surrounding the role of Th2 cytokines, such as interleukin-4 (IL-4), in tuberculosis infection. Here we demonstrate that anti-IL-4 antibody, administered as a pulse during the early or late stages of murine infection, can provide significant reductions in the b...

Full description

Saved in:
Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2008-05, Vol.88 (3), p.197-202
Main Authors: Roy, Eleanor, Brennan, John, Jolles, Stephen, Lowrie, Douglas B
Format: Article
Language:English
Subjects:
Animals
Anti-IL-13
Anti-IL-4
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - therapeutic use
Chronic Disease
Disease Models, Animal
Female
Immunotherapy
Immunotherapy - methods
Infectious Disease
Injections, Intravenous
Interleukin-13 - antagonists & inhibitors
Interleukin-13 - immunology
Interleukin-4 - antagonists & inhibitors
Interleukin-4 - immunology
Lung - microbiology
Mice
Mice, Inbred BALB C
Murine tuberculosis
Mycobacterium
Mycobacterium tuberculosis - growth & development
Mycobacterium tuberculosis - isolation & purification
Pulmonary/Respiratory
Spleen - microbiology
Tuberculosis - immunology
Tuberculosis - prevention & control
Tuberculosis - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary There remains much controversy surrounding the role of Th2 cytokines, such as interleukin-4 (IL-4), in tuberculosis infection. Here we demonstrate that anti-IL-4 antibody, administered as a pulse during the early or late stages of murine infection, can provide significant reductions in the bacterial burden. The fact that substantial benefit can be achieved when treatment is administered during established infection strengthens the view that clinical interventions aimed at suppressing the IL-4 component of the host immune response seen in tuberculosis patients may be beneficial.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2007.11.005