Cord Compression May Rapidly Influence the Expression of Placental Angiogenic Genes in Pre-Eclampsia

Abstract Gene expression studies have demonstrated the altered expression level of placental angiogenesis related genes in severe pre-eclampsia (PE). In cord compression, the transportation of oxygen from the placenta to the fetus is blocked, and it is speculated that during blockade the originally...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2008-05, Vol.29 (5), p.436-438
Main Authors: Järvenpää, J, Vuoristo, J.T, Ukkola, O, Hirvikoski, P, Savolainen, E.-R, Raudaskoski, T, Ryynänen, M
Format: Article
Language:English
Subjects:
Adult
Angiogenesis
Biological and medical sciences
Case-Control Studies
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes
Humans
Internal Medicine
Neovascularization, Physiologic - genetics
Nuchal Cord - genetics
Obstetrics and Gynecology
Placenta
Placenta - metabolism
Placental Circulation - genetics
Placental Circulation - physiology
Pre-eclampsia
Pre-Eclampsia - genetics
Pregnancy
Pregnancy Complications, Hematologic - genetics
Pregnancy Complications, Hematologic - pathology
Umbilical cord
Umbilical Cord - pathology
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Summary:Abstract Gene expression studies have demonstrated the altered expression level of placental angiogenesis related genes in severe pre-eclampsia (PE). In cord compression, the transportation of oxygen from the placenta to the fetus is blocked, and it is speculated that during blockade the originally hypoxic placenta may become hyperoxic. We compared the placental gene expression profiles of one pre-eclamptic patient with cord compression (the index patient) to the profiles of patients with PE and those of normal pregnancy controls (including one woman with cord compression). The gene expression of the cord compression PE patient resembled that observed in the normal pregnancies. We hypothesize that umbilical blockade may in a short period of time lead to placental hyperoxia, which in turn has an effect on angiogenic gene expression profile.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2008.02.010