Lipids and stroke: neglect of a useful preventive measure?

The epidemiological studies linking lipid variables and stroke are reviewed. These studies indicate that serum total cholesterol (TC) levels are associated positively with thrombotic and negatively with haemorrhagic strokes. Relationships for other lipid fractions are not as clearly defined. The res...

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Bibliographic Details
Published in:Cardiovascular research 1998-11, Vol.40 (2), p.265-271
Main Authors: Papadakis, John A, Mikhailidis, Dimitri P, Winder, Anthony F
Format: Article
Language:English
Subjects:
Arteriosclerosis - prevention & control
Atherosclerosis
Biological and medical sciences
Biomarkers - blood
Cerebrovascular Disorders - blood
Cerebrovascular Disorders - epidemiology
Cerebrovascular Disorders - etiology
Cerebrovascular Disorders - prevention & control
Cerebrovascular events
Cholesterol - blood
Clinical Trials as Topic
General and cellular metabolism. Vitamins
Humans
Hyperlipidemias - complications
Hypolipidemic Agents - pharmacology
Hypolipidemic Agents - therapeutic use
Incidence
Ischaemic heart disease
Lipid-lowering therapy
Lipids
Lipids - blood
Medical sciences
Myocardial Ischemia - prevention & control
Pharmacology. Drug treatments
Risk Factors
Statins
Stroke
Stroke prevention
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Summary:The epidemiological studies linking lipid variables and stroke are reviewed. These studies indicate that serum total cholesterol (TC) levels are associated positively with thrombotic and negatively with haemorrhagic strokes. Relationships for other lipid fractions are not as clearly defined. The results of trials with lipid lowering drugs suggest that only statins effectively reduce the incidence of stroke. Differences between trial results may be due to variation in the extent of reduction of TC levels. Possible underlying mechanisms for benefit and the apparent superiority of statins are also discussed. The reduction in the risk of thrombotic stroke with statins is most evident through meta-analyses (p
ISSN:0008-6363
1755-3245
DOI:10.1016/S0008-6363(98)00222-3