Isothiocyanate Sesquiterpenes from a Sponge of the Genus Axinyssa

The chemical study of a sponge of the genus Axinyssa collected in the Gulf of California has led to the isolation of the new bicyclic sesquiterpenes axinisothiocyanates A−L (1−12) together with the known compounds (1R,6S,7S,10S)-10-isothiocyanato-4-amorphene (13), (4R*,5R*,7S*,10R*)-4-isocyanoeudesm...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2008-04, Vol.71 (4), p.608-614
Main Authors: Zubía, Eva, Ortega, María J, Hernández-Guerrero, Claudia J, Carballo, J. Luis
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
axinisothiocyanate
Axinyssa
Biological and medical sciences
cadinane sesquiterpenes
California
chemical structure
cultured cells
cytotoxicity
Drug Screening Assays, Antitumor
General aspects
General pharmacology
Humans
isothiocyanates
Isothiocyanates - chemistry
Isothiocyanates - isolation & purification
Isothiocyanates - pharmacology
Medical sciences
medicinal properties
Molecular Structure
Oceans and Seas
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera
Porifera - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
sesquiterpenoids
spectral analysis
stereochemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The chemical study of a sponge of the genus Axinyssa collected in the Gulf of California has led to the isolation of the new bicyclic sesquiterpenes axinisothiocyanates A−L (1−12) together with the known compounds (1R,6S,7S,10S)-10-isothiocyanato-4-amorphene (13), (4R*,5R*,7S*,10R*)-4-isocyanoeudesm-11-ene, (−)-epipolasin A, and (+)-aristolone. The structures of the new metabolites have been established by spectroscopic techniques, including the analysis of pyridine-induced 1H NMR chemical shifts. The cytotoxic activity has been tested against three human tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np070593s