Novel Inhibitors of Fungal Protein Synthesis Produced by a Strain of Graphium putredinis: Isolation, Characterisation and Biological Properties

The isolation and structure determination of 6 analogues of the fungal protein synthesis inhibitor GR135402, from Graphium putredinis, is described. The relative potencies of the compounds as protein synthesis inhibitors and as in vitro antifungal agents provide interesting insights into the structu...

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Bibliographic Details
Published in:Journal of antibiotics 1998/11/25, Vol.51(11), pp.1012-1018
Main Authors: KENNEDY, TRACY C., WEBB, GRAHAM, CANNELL, RICHARD J. P., KINSMAN, OONAGH S., MIDDLETON, ROBERT F., SIDEBOTTOM, PHILIP J., TAYLOR, NICHOLAS L., DAWSON, MICHAEL J., BUSS, ANTONY D.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Biological and medical sciences
Fermentation
Fungal Proteins - biosynthesis
General pharmacology
Graphium putredinis
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Polycyclic Compounds - pharmacology
Structure-Activity Relationship
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Summary:The isolation and structure determination of 6 analogues of the fungal protein synthesis inhibitor GR135402, from Graphium putredinis, is described. The relative potencies of the compounds as protein synthesis inhibitors and as in vitro antifungal agents provide interesting insights into the structure-activity relationships in this series.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.1012