Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520: II. Physico-chemical Properties and Structure Elucidation

Topostatin is a new topoisomerase inhibitor isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The inhibitor inhibits topoisomerases I and II, and it has neither ability to stabilize the cleavable complex nor ability to intercalate into DNA strands. The molecular formula of...

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Bibliographic Details
Published in:Journal of antibiotics 1998/11/25, Vol.51(11), pp.999-1003
Main Authors: SUZUKI, KEITAROU, YAHARA, SHOJI, KIDO, YUTAKA, NAGAO, KAZUHIKO, HATANO, YUICHI, UYEDA, MASARU
Format: Article
Language:English
Subjects:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Fundamental and applied biological sciences. Psychology
General aspects
Lactams - chemistry
Lactams - pharmacology
Medical sciences
Microbiology
Molecular Structure
Pharmacology. Drug treatments
Thermomonospora alba
Topoisomerase I Inhibitors
Topoisomerase II Inhibitors
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Summary:Topostatin is a new topoisomerase inhibitor isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The inhibitor inhibits topoisomerases I and II, and it has neither ability to stabilize the cleavable complex nor ability to intercalate into DNA strands. The molecular formula of topostatin was determined as C36H58N4O11S based on the FAB-MS analyses, and the structure was elucidated to be a novel 14-membered ring containing peptide and terpenoid by various NMR spectroscopies.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.999