Diffuse large B-cell lymphoma showing an interfollicular pattern of proliferation: a study of the Osaka Lymphoma Study Group

• Published in: Histopathology 2008-05, Vol.52 (6), p.731-737
• Main Authors: Yamauchi, A, Ikeda, J, Nakamichi, I, Kohara, M, Fukuhara, S, Hino, M, Kanakura, Y, Ogawa, H, Sugiyama, H, Kanamaru, A, Aozasa, K
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Case-Control Studies; Cell Proliferation; diffuse large B-cell lymphoma; Female; Germinal Center - cytology; Hematologic and hematopoietic diseases; Humans; Immunohistochemistry; immunophenotype; interfollicular pattern; Investigative techniques, diagnostic techniques (general aspects); Japan; L-Lactate Dehydrogenase - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - pathology; Male; Medical sciences; Middle Aged; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Phenotype; Prognosis
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1111/j.1365-2559.2008.03018.x

Aims:  Diffuse large B‐cell lymphoma (DLBCL) usually proliferates effacing lymph follicles. In occasional cases, tumour cells show an interfollicular pattern of proliferation preserving lymph follicles. The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to determine whether this type of lymphoma is a distinct entity of DLBCL. Methods and results:  Clinicopathological findings in 12 cases of DLBCL showing an interfollicular pattern of proliferation [interfollicular group (IF)] were examined and compared with those in 30 cases of DLBCL with ordinary morphology [control group (CG)]. IF showed a significantly lower lactate dehydrogenase level and International Prognostic Index scores than CG (P = 0.023 and P