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Autoreactivity versus autoaggression: a different perspective on human autoantigens
Antigen-specific B and T cell responses against myelin basic protein, as well as responses against β-islet-cells or joint tissue, are commonly found both in patients with autoimmune disease and in normal control subjects with disease-associated HLA-DR/DQ alleles. Thus, autoreactive immune responses...
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Published in: | Current opinion in immunology 1998-12, Vol.10 (6), p.663-668 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Antigen-specific B and T cell responses against myelin basic protein, as well as responses against β-islet-cells or joint tissue, are commonly found both in patients with autoimmune disease and in normal control subjects with disease-associated HLA-DR/DQ alleles. Thus, autoreactive immune responses are not disease-specific; however, the presence of certain autoantibodies may have prognostic value and may aid in disease management. |
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ISSN: | 0952-7915 1879-0372 |
DOI: | 10.1016/S0952-7915(98)80086-1 |