Significance of the minor i and t determinants of hepatitis B virus in hepatocellular carcinoma

Stored sera from asymptomatic hepatitis B virus (HBV) carriers and hepatitis B virus surface antigen-positive hepatocellular carcinoma (HCC) patients were tested for HBV subtypes, such as subtype determinants d, y, w, r and also antigenic determinants isoleucine (i) and threonine (t) by direct S gen...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 1998-12, Vol.13 (12), p.1237-1240
Main Authors: YI ZHAO, OON, C. J, LIM, G. K
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Hepatocellular - virology
DNA, Viral - blood
Epitopes - blood
Epitopes - genetics
Epitopes - immunology
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis B Surface Antigens - blood
Hepatitis B Surface Antigens - genetics
Hepatitis B Surface Antigens - immunology
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Humans
Liver Neoplasms - virology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Middle Aged
Polymerase Chain Reaction
Tropical medicine
Tumors
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Summary:Stored sera from asymptomatic hepatitis B virus (HBV) carriers and hepatitis B virus surface antigen-positive hepatocellular carcinoma (HCC) patients were tested for HBV subtypes, such as subtype determinants d, y, w, r and also antigenic determinants isoleucine (i) and threonine (t) by direct S gene nucleotide sequencing. Significant changes in minor i and t determinants in hepatocellular carcinoma patients with adr hepatitis B carriers were seen. The adr subtype with t determinant was present in 14/25 (56%) of HCC patients compared with only two of 28 (7%) in asymptomatic hepatitis B carriers (P
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.1998.tb00611.x