Pathogenicity and Lethality of a Minute Intestinal Fluke, Neodiplostomum seoulense, to Various Strains of Mice

Pathogenicity and lethality of Neodiplostomum seoulense to various strains of mice (mast cell-deficient W/Wv, their normal littermate +/+, C57BL/6, BALB/cA, C3H/HeJ), and a hybrid (BALB/cA x C3H/HeJ)F1 were investigated. When the mice were infected orally each with 200 metacercariae, their abdomen b...

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Bibliographic Details
Published in:The Journal of parasitology 1998-12, Vol.84 (6), p.1178-1183
Main Authors: Kook, Jina, Nawa, Yukifumi, Lee, Soon-Hyung, Chai, Jong-Yil
Format: Article
Language:English
Subjects:
Animals
Antiplatyhelmintic Agents - therapeutic use
Biological and medical sciences
Charcoal
Dosage
Eggs
Feces
Feces - parasitology
Fundamental and applied biological sciences. Psychology
Gastrointestinal Transit
Host parasite relation
pathogenicity
Infections
Intestines
Intestines - parasitology
Intestines - pathology
Intestines - physiopathology
Invertebrates
Male
Memory interference
Metacercariae
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Nemathelminthia. Plathelmintha
Parasite Egg Count
Parasitology
Pathology
Praziquantel - therapeutic use
Specific Pathogen-Free Organisms
Survival rates
Trematoda - pathogenicity
Trematode Infections - drug therapy
Trematode Infections - mortality
Trematode Infections - parasitology
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Summary:Pathogenicity and lethality of Neodiplostomum seoulense to various strains of mice (mast cell-deficient W/Wv, their normal littermate +/+, C57BL/6, BALB/cA, C3H/HeJ), and a hybrid (BALB/cA x C3H/HeJ)F1 were investigated. When the mice were infected orally each with 200 metacercariae, their abdomen became distended, and all mice died by day 23 postinfection (PI) except BALB/cA, which were severely weakened but recovered after 28 days. Even a smaller infection dose of 25 metacercariae was highly lethal to C3H/HeJ mice. Despite treatment with praziquantel (3 mg/mouse) on day 10 PI, 80% of C57BL/6 mice did not recover and died. After day 14 PI, the whole intestine of C57BL/6 mice was contracted and significantly shortened in length, and charcoal meal transit was significantly faster compared with uninfected controls. After incubation in papaverine, the contracted intestines of C3H/HeJ mice did not relax, suggesting that the change is irreversible. In conclusion, N. seoulense has the potential to kill most strains of mice by causing irreversible damage to their intestine. The effects of mucosal mast cells on the survival rate of mice were negligible, because both W/Wv and +/+ mice died around day 20 PI.
ISSN:0022-3395
1937-2345
DOI:10.2307/3284669