Pre-treatment white blood cell subtypes as prognostic indicators in ovarian cancer

Abstract Objective Inflammatory cells can both suppress and stimulate tumour growth and their influence on clinical outcome in cancer patients has been studied in various cancer types. Here we have investigated their influence on outcome in primary epithelial ovarian cancer. Study design Serum white...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2008-05, Vol.138 (1), p.71-75
Main Authors: Bishara, S, Griffin, M, Cargill, A, Bali, A, Gore, M.E, Kaye, S.B, Shepherd, J.H, Van Trappen, P.O
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Leukocyte Count
Lymphocytes
Medical sciences
Middle Aged
Monocytes
Neutrophils
Obstetrics and Gynecology
Ovarian cancer
Ovarian Neoplasms - immunology
Ovarian Neoplasms - surgery
Prognosis
Survival Analysis
Treatment Outcome
Tumors
White blood cells
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Summary:Abstract Objective Inflammatory cells can both suppress and stimulate tumour growth and their influence on clinical outcome in cancer patients has been studied in various cancer types. Here we have investigated their influence on outcome in primary epithelial ovarian cancer. Study design Serum white blood cell numbers according to subtype were recorded prior to treatment in 136 patients with primary epithelial ovarian cancer. Their correlation with overall survival and disease-free survival was analysed using both univariate and multivariate analysis adjusting for the known prognostic factors (age, stage and debulking status). Results Multivariate analysis demonstrated that a lower lymphocyte fraction of total white blood cells was significantly associated with mortality ( p < 0.01). On univariate analysis ( p = 0.0027, HR = 1.15), and multivariate analysis of those patients who were optimally debulked ( p = 0.036, HR = 1.17), a higher monocyte count was significantly associated with recurrence. On multivariate analysis amongst those who were suboptimally debulked, a higher eosinophil count was predictive of both recurrence ( p = 0.0037, HR = 1.77) and mortality ( p = 0.033, HR = 1.73). Conclusion High monocyte counts amongst those who were optimally debulked independently predict adverse outcome in primary epithelial ovarian cancer.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2007.05.012