Expressed major histocompatibility complex class II loci in fishes

Peptides derived from parasites are presented to T helper cells by major histocompatibility complex (MHC) class II αβ heterotrimeric cell‐surface molecules. In mice and humans, the genes encoding these antigen‐presenting molecules are known to be polymorphic and poly‐genic. Multiple loci for MHC cla...

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Bibliographic Details
Published in:Immunological reviews 1998-12, Vol.166 (1), p.294-300
Main Authors: McConnell, Thomas J., Godwin, Ulla B., Cuthbertson, Brandon J.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Brackish
Evolution, Molecular
Exons
Fishes - genetics
Fishes - immunology
Freshwater
Gene Expression
Genes, MHC Class II
Humans
Introns
Marine
Mice
Molecular Sequence Data
Teleostei
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Summary:Peptides derived from parasites are presented to T helper cells by major histocompatibility complex (MHC) class II αβ heterotrimeric cell‐surface molecules. In mice and humans, the genes encoding these antigen‐presenting molecules are known to be polymorphic and poly‐genic. Multiple loci for MHC class II A and E genes are proposed to allow for an increased peptide‐binding repertoire. The multigenic nature of expressed MHC class II loci and the differences between these loci in fishes are the focus of this review, Particular emphasis is placed on an evolutionary comparison of class II B loci, especially two class 11 B loci that have undergone dramatic changes from one another suggesting an ancestral gene duplication event that took place at an early stage in the evolution of teleosts, The number of functional class II αβ loci heterotrimers may have a profound impact on the organisms ability to battle constantly evolving parasitic infections.
ISSN:0105-2896
1600-065X
DOI:10.1111/j.1600-065X.1998.tb01270.x