Association Between Plasma Pregnancy-Associated Plasma Protein A and Restenosis After Percutaneous Coronary Angioplasty

• Published in: Circulation Journal 2008, Vol.72(5), pp.729-733
• Main Authors: Li, Xu-Ping, Zhou, Sheng Hua, Tang, Jian Jun, Liu, Qi Ming, Fang, Zheng Fei, Hu, Xing Qun, Zhou, Tao, Sheng, Xiang Qian, Zhao, Shui Ping
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty; Angioplasty, Balloon, Coronary; Biomarkers - blood; Coronary Artery Disease - blood; Coronary Artery Disease - epidemiology; Coronary Artery Disease - therapy; Coronary Restenosis - blood; Coronary Restenosis - diagnosis; Coronary Restenosis - epidemiology; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Plasma pregnancy-associated plasma protein-A; Predictive Value of Tests; Pregnancy-Associated Plasma Protein-A - metabolism; Prospective Studies; Restenosis
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.72.729

Background Restenosis after percutaneous coronary angioplasty remains an important limitation of this procedure. This study evaluates the association between plasma pregnancy-associated plasma protein A (PAPP-A) levels and restenosis after coronary angioplasty. Methods and Results Blood samples were collected from all patients at baseline, and their levels of PAPP-A, inflammation (high-sensitivity C-reactive protein (hsCRP)) and platelet activation (soluble CD40 ligand (sCD40L)) were determined. Those patients whose PCI was successful underwent a repeat angiography at a median of 6.4 months (interquartile range 6-9.8 months). Their baseline and follow-up angiograms were compared by quantitative coronary angiography to assess the incidence of restenosis. Endpoints were restenosis (≥50%) and a composite of major adverse cardiac events. Of the 184 patients, 162 patients underwent an angiographic follow up at 6 months. Patients with restenosis had significantly higher PAPP-A levels than those without (19.24±2.56 vs 11.95±2.32 mIu/L; p