The life-shortening effect of reduced physical activity is abolished by a fat rich diet

In female mice on a control diet (3.6% fat) reduced physical activity leads to a reduction of the average life span. So the average age at death of an inactive group is 500±166 compared to 565±175 days in an active control group. If the animals are kept on a fat rich diet (12.4% fat) this effect of...

Full description

Saved in:
Bibliographic Details
Published in:Mechanisms of ageing and development 1998-09, Vol.105 (1), p.61-73
Main Authors: Mlekusch, Walter, Tillian, Manfred, Lamprecht, Manfred, Oettl, Karl, Krainz, Hannes, Reibnegger, Gilbert
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Weight
Dietary Fats - metabolism
Eating
Fat diet
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Incidence
Longevity
Mice
Mobility restriction
Neoplasms - epidemiology
Organ Size
Physical Conditioning, Animal - physiology
Stress
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In female mice on a control diet (3.6% fat) reduced physical activity leads to a reduction of the average life span. So the average age at death of an inactive group is 500±166 compared to 565±175 days in an active control group. If the animals are kept on a fat rich diet (12.4% fat) this effect of physical activity restriction is no longer observable and the average age at death is 570±142 days, within the range of the control animals. The increased fat intake seems to reduce the stress or to increase the resistance to stress in the activity restricted animals. So stress is a crucial determinant of life span.
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(98)00080-3