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Complement activation in discordant hepatic xenotransplantation

: Little is known about hyperacute rejection in hepatic xenotransplantation. Information from clinical xenoperfusions suggests that the liver may be rejected by a mechanism less vigorous than either kidney or heart xenografts. We used the in vitro model of porcine hepatic sinusoidal endothelial cell...

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Bibliographic Details
Published in:Xenotransplantation (Københaven) 1998-11, Vol.5 (4), p.257-261
Main Authors: Tector, A. Joseph, Chen, Xuwu, Soderland, Carl, Tchervenkov, Jean I.
Format: Article
Language:English
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Summary:: Little is known about hyperacute rejection in hepatic xenotransplantation. Information from clinical xenoperfusions suggests that the liver may be rejected by a mechanism less vigorous than either kidney or heart xenografts. We used the in vitro model of porcine hepatic sinusoidal endothelial cells (PHEC) incubated with either complement replete or deficient human serum to determine the relative roles of the classical and alternate pathways of complement in the immediate response to hepatic xenotransplantation. Our results suggest that either the classical or alternate pathways are capable of independently activating the complement cascade upon exposure to the porcine hepatic sinusoidal endothelium. Our results also imply that either pathway alone is capable of initiating similar degrees of injury as the entire cascade.
ISSN:0908-665X
1399-3089
DOI:10.1111/j.1399-3089.1998.tb00036.x