Immunization strategies against visceral leishmaniosis with the nucleosomal histones of Leishmania infantum encoded in DNA vaccine or pulsed in dendritic cells

Summary Immunization of BALB/c mice with a DNA vaccine encoding the nucleosomal histones from Leishmania infantum resulted in a complete failure of protection against visceral leishmaniosis (VL), whereas the adoptive transfer of bone marrow-derived dendritic cells pulsed with the same pathoantigens...

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Bibliographic Details
Published in:Vaccine 2008-05, Vol.26 (20), p.2537-2544
Main Authors: Carrión, Javier, Folgueira, Cristina, Alonso, Carlos
Format: Article
Language:English
Subjects:
Adoptive Transfer - methods
Allergy and Immunology
Animals
Antibodies, Protozoan - blood
Antigens, Protozoan - genetics
Antigens, Protozoan - immunology
Applied microbiology
Biological and medical sciences
Dendritic cell
Dendritic Cells - immunology
DNA vaccine
Female
Fundamental and applied biological sciences. Psychology
Histones
Histones - immunology
Human protozoal diseases
Immunoglobulin G - blood
Infectious diseases
Leishmania
Leishmania infantum
Leishmania infantum - immunology
Leishmaniasis, Visceral - prevention & control
Leshmaniasis
Liver - parasitology
Medical sciences
Mice
Mice, Inbred BALB C
Microbiology
Parasitic diseases
Protozoal diseases
Protozoan Proteins - genetics
Protozoan Proteins - immunology
Spleen - immunology
Spleen - parasitology
T-Lymphocytes, Regulatory - immunology
Treg cell
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - genetics
Vaccines, DNA - immunology
Visceral leishmaniosis
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Summary:Summary Immunization of BALB/c mice with a DNA vaccine encoding the nucleosomal histones from Leishmania infantum resulted in a complete failure of protection against visceral leishmaniosis (VL), whereas the adoptive transfer of bone marrow-derived dendritic cells pulsed with the same pathoantigens plays an essential role in controlling parasite growth in half of the cases. Reduction of the visceral parasite burden seems to be related to low persistence of regulatory T-cells in the spleen from vaccinated mice. These results provide clues for the optimization of this vaccine strategy with the four Leishmania nucleosomal histones against L. infantum infection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.03.003