Tumour necrosis factor-alpha and lymphotoxin-alpha in the pathology of experimental autoimmune encephalomyelitis: is either one responsible or is there another ligand-mediating disease?

This paper examines the conflicting data concerning the respective roles for tumour necrosis factor-alpha (TNF alpha ) and lymphotoxin-alpha (LT alpha ) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). We present new data using TNF receptor-deficient mice rather than cytokine-...

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Bibliographic Details
Published in:Research in immunology (Paris) 1998-11, Vol.149 (9), p.804-810
Main Authors: Willenborg, D.O., Fordham, S.A., O'Brien, N.C., Cowden, W.B., Ramshaw, I.A.
Format: Article
Language:English
Subjects:
Animals
Encephalomyelitis, Autoimmune, Experimental - immunology
Humans
Ligands
Lymphotoxin-alpha - immunology
Tumor Necrosis Factor-alpha - immunology
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Summary:This paper examines the conflicting data concerning the respective roles for tumour necrosis factor-alpha (TNF alpha ) and lymphotoxin-alpha (LT alpha ) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). We present new data using TNF receptor-deficient mice rather than cytokine-deficient mice, and propose the possible existence of a new ligand which interacts with the TNFR1 (p55) in the mediation of disease.
ISSN:0923-2494
DOI:10.1016/S0923-2494(99)80008-X