Renin and Hemodynamic Responses to Exercise in Borderline Hypertensives

Objective.—In this study, we examined the relationship between baseline plasma renin (REN) and hemodynamic variables during recovery from aerobic exercise in 10 Caucasian (C) and 10 African-American (AA) borderline hypertensive females. Methods.—Subjects attended three preliminary sessions and an ex...

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Bibliographic Details
Published in:Ethnicity & disease 1998-10, Vol.8 (3), p.312-318
Main Authors: Headley, Samuel A., Keenan, Thomas G., Keenan, Thomas J., Manos, Tina M., Phillips, Kim, Lachowetz, Tony, Keenan, Hillary A., Mahar, Matthew T.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Black or African American
Black People
Blood Pressure
Exercise - physiology
Female
Heart Rate
Hemodynamics
Humans
Hypertension - blood
Hypertension - genetics
Hypertension - physiopathology
Middle Aged
Original Reports
Regression Analysis
Renin - blood
Vascular Resistance
White People
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Summary:Objective.—In this study, we examined the relationship between baseline plasma renin (REN) and hemodynamic variables during recovery from aerobic exercise in 10 Caucasian (C) and 10 African-American (AA) borderline hypertensive females. Methods.—Subjects attended three preliminary sessions and an experimental session in which treadmill walking was performed for 40 minutes at a moderate intensity. During this session, blood was drawn at baseline prior to exercise and immediately following. Blood pressure and other hemodynamic variables were recorded at rest before exercise and for 2 hours afterwards. The average difference from baseline during the two hour recovery period was calculated for each variable and used as the dependent variable in a multiple regression analysis. Results.—For mean arterial pressure and cardiac output, the regression slopes did not differ between AA and However, during recovery, the average difference from baseline for systemic vascular resistance (SVR) increased in AA but decreased in C. Conclusion.—In conclusion, REN had a significant effect on SVR but no effect on the other hemodynamic variables during recovery from aerobic exercise. It appears as if the peripheral vasculature in AA may be more sensitive than in C to the vasoconstrictive effects of the renin angiotensin system.
ISSN:1049-510X
1945-0826