NM23-NDP kinase

NM23 belongs to a large family of structurally and functionally conserved proteins consisting of 4–6 identically folded subunits of approximately 16–20 kDa. These oligomeric proteins exhibit nucleoside diphosphate kinase (NDPK) activity that catalyzes nonsubstrate specific conversions of nucleoside...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 1998-12, Vol.30 (12), p.1291-1295
Main Author: Postel, Edith H.
Format: Article
Language:English
Subjects:
Animals
AWD
Biomarkers, Tumor
c- myc
Differentiation
DNA - metabolism
DNA-binding
Gene Expression Regulation
Humans
Metastasis
Models, Molecular
Monomeric GTP-Binding Proteins
NDPK
NM23
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase - genetics
Nucleoside-Diphosphate Kinase - physiology
Protein Conformation
Transcription Factors - genetics
Transcription Factors - physiology
Transcription, Genetic
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Description
Summary:NM23 belongs to a large family of structurally and functionally conserved proteins consisting of 4–6 identically folded subunits of approximately 16–20 kDa. These oligomeric proteins exhibit nucleoside diphosphate kinase (NDPK) activity that catalyzes nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. Many NM23 proteins bind DNA. In vivo, NM23–NDPKs regulate a diverse array of cellular events including growth and development. They are also implicated in the pathogenesis and metastasis of tumors. The mechanism whereby NM23 regulates gene expression is proposed to entail DNA-binding and subsequent alterations in promoter DNA structure. Accordingly, NM23 has the potential to become a useful reagent for gene manipulations.
ISSN:1357-2725
1878-5875
DOI:10.1016/S1357-2725(98)00087-9