Increased production of β-defensin 3 (hBD-3) by human amniotic epithelial cells (HAEC) after activation of toll-like receptor 4 in chorioamnionitis

Placenta and fetal membranes may become exposed to pathogenic microorganisms which may influence the embryo/fetus health. Recent investigations suggest that the placental unit may function as an active barrier, recognizing and responding to pathogens via toll-like receptors (TLRs). The TLR4 recogniz...

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Bibliographic Details
Published in:Inflammation research 2008-04, Vol.57 (Suppl 1), p.67-68
Main Authors: Szukiewicz, D., Szewczyk, G., Pyzlak, M., Klimkiewicz, J., Maslinska, D.
Format: Article
Language:English
Subjects:
Allergology
Amnion - cytology
Amnion - drug effects
Animals
beta-Defensins - metabolism
Biomedical and Life Sciences
Biomedicine
Cells, Cultured
Chorioamnionitis - metabolism
Dermatology
Epithelial Cells - cytology
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Female
Humans
Immunology
Lipopolysaccharides - pharmacology
Neurology
Pharmacology/Toxicology
Pregnancy
Rheumatology
Toll-Like Receptor 4 - metabolism
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Summary:Placenta and fetal membranes may become exposed to pathogenic microorganisms which may influence the embryo/fetus health. Recent investigations suggest that the placental unit may function as an active barrier, recognizing and responding to pathogens via toll-like receptors (TLRs). The TLR4 recognize lipopolysaccharide (LPS) microbial endotoxins associated with gram-negative bacteria. Various antimicrobial molecules are expressed on the surfaces of monocytes and epithelial cells. Human amniotic epithelial cells (HAEC) produce antimicrobial beta -defensins, especially human beta -defensin 3 (hBD-3). Here we comparatively examined in vitro, influence of LPS on hBD-3 synthesis in normal HAEC and obtained after chorioamnionitis.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-007-0633-z