The relationship between human β-defensin 3 (hBD3) expression and mean histamine concentration in human placental tissue

Human defensins are small cationic, cysteine-rich peptides with a wide range of antimicrobial activities. Human beta -defensin-3 is widely expressed in placentae and exhibits antimicrobial activity against a number of human pathogens; multiresistant Gram-postitive Staphylococcus aureus, vancomycin-r...

Full description

Saved in:
Bibliographic Details
Published in:Inflammation research 2008-04, Vol.57 (Suppl 1), p.69-70
Main Authors: Szukiewicz, D., Klimkiewicz, J., Pyzlak, M., Szukiewicz, A., Maslinska, D.
Format: Article
Language:English
Subjects:
Allergology
beta-Defensins - metabolism
Biomedical and Life Sciences
Biomedicine
Candida albicans
Chorioamnionitis - metabolism
Dermatology
Enterococcus faecium
Escherichia coli
Female
Histamine - metabolism
Humans
Immunology
Neurology
Pharmacology/Toxicology
Placenta - cytology
Placenta - metabolism
Pregnancy
Pseudomonas aeruginosa
Rheumatology
Staphylococcus aureus
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human defensins are small cationic, cysteine-rich peptides with a wide range of antimicrobial activities. Human beta -defensin-3 is widely expressed in placentae and exhibits antimicrobial activity against a number of human pathogens; multiresistant Gram-postitive Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, Gram-negative Pseudomonas aeruginosa and Escherichia coli and the yeast Candida albicans. When stimulated by bacterial infections and by interferon gamma, the amnion and placental cells produce hBD-3. Human placental tissue contains a moderate amount of histamine (HA) in vesicular structures in mast cells. As hBD-3 induces HA release from mast cells, we examined the relationship between placental hBD-3 expression and mean HA concentration in placental tissue in normal (N = 12; group II) and chorioamnionitis-complicated pregnancies (N = 12; group I).
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-007-0634-y