Interactions between Epithelial Cells and Immune Cells in the Intestine

Not merely a passive barrier as previously assumed, epithelial cells act as sensitive indicators of infection that initiate defense responses. Noninvasive as well as invasive organisms have been demonstrated to elicit production of chemoattractants. That noninvasive organisms have this capacity sugg...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1998-11, Vol.859 (1), p.37-45
Main Author: STROBER, WARREN
Format: Article
Language:English
Subjects:
Animals
Chemokines - physiology
Cytokines - physiology
Entamoeba histolytica - pathogenicity
Escherichia coli - pathogenicity
Escherichia coli - physiology
Helicobacter pylori - pathogenicity
Helicobacter pylori - physiology
Humans
Immunity, Mucosal - physiology
Intestinal Mucosa - microbiology
Intestinal Mucosa - parasitology
Intestinal Mucosa - physiology
Signal Transduction
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Summary:Not merely a passive barrier as previously assumed, epithelial cells act as sensitive indicators of infection that initiate defense responses. Noninvasive as well as invasive organisms have been demonstrated to elicit production of chemoattractants. That noninvasive organisms have this capacity suggests that receptor‐mediated signaling pathways may be involved. Epithelial cells have been found to release both chemokines and cytokines in a precise mixture that varies according to the origin or maturity of the cell. Different microorganisms also elicit different response patterns. The information presented provides a basis for a new view of epithelial cell function in relation to host defense.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1998.tb11109.x