Coprophilin: An anticoccidial agent produced by a dung inhabiting fungus

Coprophilin, a decalin pentanedienoic acid methyl ester, was isolated from an unidentified fungus by bioassay guided separation. It inhibited (MIC = 1.5 μM) the growth of Eimeria tenella in an in vitro assay. The isolation, structure elucidation, absolute stereochemistry and biology are described. C...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-12, Vol.8 (24), p.3439-3442
Main Authors: Ondeyka, John G., Giacobbe, Robert A., Bills, Gerald F., Cuadrillero, Cristina, Schmatz, Dennis, Goetz, Michael A., Zink, Deborah L., Singh, Sheo B.
Format: Article
Language:English
Subjects:
Alkenes - chemical synthesis
Alkenes - chemistry
Alkenes - pharmacology
Animals
Biological and medical sciences
Cattle
Cell Line
Chemical control
Coccidiostats - chemistry
Coccidiostats - pharmacology
Control
Eimeria tenella - drug effects
Esters - chemical synthesis
Esters - chemistry
Esters - pharmacology
Feces - microbiology
Fundamental and applied biological sciences. Psychology
Fungi - metabolism
Microbiology
Molecular Structure
Morphology, structure, chemical composition
Mycology
Phytopathology. Animal pests. Plant and forest protection
Protozoa. Invertebrates
Spectrometry, Mass, Fast Atom Bombardment
Stereoisomerism
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Summary:Coprophilin, a decalin pentanedienoic acid methyl ester, was isolated from an unidentified fungus by bioassay guided separation. It inhibited (MIC = 1.5 μM) the growth of Eimeria tenella in an in vitro assay. The isolation, structure elucidation, absolute stereochemistry and biology are described. Coprophilin, a decalin pentanedienoic acid methyl ester, was isolated from an unidentified fungus by bioassay guided separation. It inhibited (MIC = 1.5 μM) the growth of Eimeria tenella in an in vitro assay. The isolation, structure elucidation, absolute stereochemistry and biology are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00629-5