Novel DNA Catalysts Based on G-Quadruplex Recognition

An unlikely hero: Selective small‐molecule recognition of a specific DNA secondary structure, instead of hybridization, can be exploited to template catalysis between two reactants. Here, we show that a proline‐tethered quadruplex DNA, as shown in the figure, can serve as catalyst for the aldol reac...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2008-05, Vol.9 (7), p.1061-1064
Main Authors: Tang, Zhuo, Gonçalves, Diana P.N, Wieland, Markus, Marx, Andreas, Hartig, Jörg S
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
aldol reaction
Catalysis
DNA - chemistry
DNA catalysis
DNA-templated reaction
G quadruplexes
Hero
porphyrins
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Summary:An unlikely hero: Selective small‐molecule recognition of a specific DNA secondary structure, instead of hybridization, can be exploited to template catalysis between two reactants. Here, we show that a proline‐tethered quadruplex DNA, as shown in the figure, can serve as catalyst for the aldol reaction between a porphyrin‐bearing aldehyde and a ketone.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200800024