Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria

Abstract Objective To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma. Method Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 wi...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2008-06, Vol.101 (3), p.239-244
Main Authors: Pan, Hong, Sun, Chao-Chao, Zhou, Cai-Yun, Huang, He-Feng
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood supply
Adenocarcinoma - metabolism
Adult
Antigens, CD34 - analysis
Antigens, CD34 - immunology
Aquaporin 1 - blood
Aquaporin 1 - metabolism
Aquaporin-1
Biological and medical sciences
Carcinoma, Endometrioid - blood supply
Carcinoma, Endometrioid - metabolism
Carcinoma, Endometrioid - pathology
Endometrial carcinoma
Endometrial hyperplasia
Endometrial Hyperplasia - immunology
Endometrial Neoplasms - blood supply
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - pathology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Medical Records
Medical sciences
Microcirculation - pathology
Middle Aged
Neovascularization, Pathologic - metabolism
Obstetrics and Gynecology
Pathogenesis
Tumors
Vascular Endothelial Growth Factors
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Summary:Abstract Objective To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma. Method Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 with endometrial hyperplasia, and 25 with normal proliferative endometria. Results AQP1 was located in the epithelial cells of microvessels and small vessels in all samples. The AQP1/IMD ratio was highest in samples from the first, less in samples from the second, and least in samples from the third group. In samples from endometrioid adenocarcinoma, the AQP1/IMD ratio was significantly correlated with histologic grade, surgical stage, myometrial invasion, and extrauterine metastasis. There was a positive correlation between AQP1 expression and IMD and between AQP1/IMD ratio and VEGF expression. Conclusion AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis, and AQP1 level may be both a tumor indicator and a new therapeutic target.
ISSN:0020-7292
1879-3479
DOI:10.1016/j.ijgo.2007.12.006