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Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria
Abstract Objective To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma. Method Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 wi...
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| Published in: | International journal of gynecology and obstetrics 2008-06, Vol.101 (3), p.239-244 |
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| container_end_page | 244 |
| container_issue | 3 |
| container_start_page | 239 |
| container_title | International journal of gynecology and obstetrics |
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| creator | Pan, Hong Sun, Chao-Chao Zhou, Cai-Yun Huang, He-Feng |
| description | Abstract Objective To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma. Method Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 with endometrial hyperplasia, and 25 with normal proliferative endometria. Results AQP1 was located in the epithelial cells of microvessels and small vessels in all samples. The AQP1/IMD ratio was highest in samples from the first, less in samples from the second, and least in samples from the third group. In samples from endometrioid adenocarcinoma, the AQP1/IMD ratio was significantly correlated with histologic grade, surgical stage, myometrial invasion, and extrauterine metastasis. There was a positive correlation between AQP1 expression and IMD and between AQP1/IMD ratio and VEGF expression. Conclusion AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis, and AQP1 level may be both a tumor indicator and a new therapeutic target. |
| doi_str_mv | 10.1016/j.ijgo.2007.12.006 |
| format | article |
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Method Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 with endometrial hyperplasia, and 25 with normal proliferative endometria. Results AQP1 was located in the epithelial cells of microvessels and small vessels in all samples. The AQP1/IMD ratio was highest in samples from the first, less in samples from the second, and least in samples from the third group. In samples from endometrioid adenocarcinoma, the AQP1/IMD ratio was significantly correlated with histologic grade, surgical stage, myometrial invasion, and extrauterine metastasis. There was a positive correlation between AQP1 expression and IMD and between AQP1/IMD ratio and VEGF expression. Conclusion AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis, and AQP1 level may be both a tumor indicator and a new therapeutic target.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2007.12.006</identifier><identifier>PMID: 18313673</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adenocarcinoma - blood supply ; Adenocarcinoma - metabolism ; Adult ; Antigens, CD34 - analysis ; Antigens, CD34 - immunology ; Aquaporin 1 - blood ; Aquaporin 1 - metabolism ; Aquaporin-1 ; Biological and medical sciences ; Carcinoma, Endometrioid - blood supply ; Carcinoma, Endometrioid - metabolism ; Carcinoma, Endometrioid - pathology ; Endometrial carcinoma ; Endometrial hyperplasia ; Endometrial Hyperplasia - immunology ; Endometrial Neoplasms - blood supply ; Endometrial Neoplasms - metabolism ; Endometrial Neoplasms - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Medical Records ; Medical sciences ; Microcirculation - pathology ; Middle Aged ; Neovascularization, Pathologic - metabolism ; Obstetrics and Gynecology ; Pathogenesis ; Tumors ; Vascular Endothelial Growth Factors</subject><ispartof>International journal of gynecology and obstetrics, 2008-06, Vol.101 (3), p.239-244</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2008 International Federation of Gynecology and Obstetrics</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5539-5261b5c1c98bab8ff405dc55a723cdebaccff514c621941a5f185a4e1ffb95d33</citedby><cites>FETCH-LOGICAL-c5539-5261b5c1c98bab8ff405dc55a723cdebaccff514c621941a5f185a4e1ffb95d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20327691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18313673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Hong</creatorcontrib><creatorcontrib>Sun, Chao-Chao</creatorcontrib><creatorcontrib>Zhou, Cai-Yun</creatorcontrib><creatorcontrib>Huang, He-Feng</creatorcontrib><title>Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objective To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma. Method Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 with endometrial hyperplasia, and 25 with normal proliferative endometria. Results AQP1 was located in the epithelial cells of microvessels and small vessels in all samples. The AQP1/IMD ratio was highest in samples from the first, less in samples from the second, and least in samples from the third group. In samples from endometrioid adenocarcinoma, the AQP1/IMD ratio was significantly correlated with histologic grade, surgical stage, myometrial invasion, and extrauterine metastasis. There was a positive correlation between AQP1 expression and IMD and between AQP1/IMD ratio and VEGF expression. Conclusion AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis, and AQP1 level may be both a tumor indicator and a new therapeutic target.</description><subject>Adenocarcinoma - blood supply</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adult</subject><subject>Antigens, CD34 - analysis</subject><subject>Antigens, CD34 - immunology</subject><subject>Aquaporin 1 - blood</subject><subject>Aquaporin 1 - metabolism</subject><subject>Aquaporin-1</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Endometrioid - blood supply</subject><subject>Carcinoma, Endometrioid - metabolism</subject><subject>Carcinoma, Endometrioid - pathology</subject><subject>Endometrial carcinoma</subject><subject>Endometrial hyperplasia</subject><subject>Endometrial Hyperplasia - immunology</subject><subject>Endometrial Neoplasms - blood supply</subject><subject>Endometrial Neoplasms - metabolism</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Microcirculation - pathology</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Obstetrics and Gynecology</subject><subject>Pathogenesis</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factors</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkkFv1DAQhS0EokvhD3BAucCpWTx2HCcSQkJVKUUVPQBny3HG4JDYqb2h3X-Po12BxAFx8sHfG795foQ8B7oFCvXrYeuGb2HLKJVbYFtK6wdkA41sS17J9iHZUMpoKVnLTsiTlAZKKUiAx-QEGg68lnxDPl3czxFTcsEXwRb6dtFziM6XUDhf-BAnPZ4V3_czxnnUyZmzQvu-MDoa58Okd2FJBfo-TLiLTj8lj6weEz47nqfk6_uLL-cfyuuby6vzd9elEYK3pWA1dMKAaZtOd421FRV9vtKScdNjp42xVkBlagZtBVpYaISuEKztWtFzfkpeHebOMdwumHZqcsngOGqP2ZGqW5BVLeoMsgNoYkgpolVzdJOOewVUrSmqQa0pqjVFBUzlFLPoxXH60k3Y_5EcY8vAyyOgk9Gjjdobl35zjHIms4XMyQN350bc_8fT6urj5Q3jbVa-OSgxp_jTYVTJOPQGexfR7FQf3L83ePuX3IzOu-z1B-4xDWGJPv-PApWyQH1em7IWhTZrSSrOfwFczbb1</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Pan, Hong</creator><creator>Sun, Chao-Chao</creator><creator>Zhou, Cai-Yun</creator><creator>Huang, He-Feng</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria</title><author>Pan, Hong ; Sun, Chao-Chao ; Zhou, Cai-Yun ; Huang, He-Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5539-5261b5c1c98bab8ff405dc55a723cdebaccff514c621941a5f185a4e1ffb95d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - blood supply</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adult</topic><topic>Antigens, CD34 - analysis</topic><topic>Antigens, CD34 - immunology</topic><topic>Aquaporin 1 - blood</topic><topic>Aquaporin 1 - metabolism</topic><topic>Aquaporin-1</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Endometrioid - blood supply</topic><topic>Carcinoma, Endometrioid - metabolism</topic><topic>Carcinoma, Endometrioid - pathology</topic><topic>Endometrial carcinoma</topic><topic>Endometrial hyperplasia</topic><topic>Endometrial Hyperplasia - immunology</topic><topic>Endometrial Neoplasms - blood supply</topic><topic>Endometrial Neoplasms - metabolism</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Microcirculation - pathology</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Obstetrics and Gynecology</topic><topic>Pathogenesis</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Hong</creatorcontrib><creatorcontrib>Sun, Chao-Chao</creatorcontrib><creatorcontrib>Zhou, Cai-Yun</creatorcontrib><creatorcontrib>Huang, He-Feng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Hong</au><au>Sun, Chao-Chao</au><au>Zhou, Cai-Yun</au><au>Huang, He-Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2008-06</date><risdate>2008</risdate><volume>101</volume><issue>3</issue><spage>239</spage><epage>244</epage><pages>239-244</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Abstract Objective To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma. Method Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 with endometrial hyperplasia, and 25 with normal proliferative endometria. Results AQP1 was located in the epithelial cells of microvessels and small vessels in all samples. The AQP1/IMD ratio was highest in samples from the first, less in samples from the second, and least in samples from the third group. In samples from endometrioid adenocarcinoma, the AQP1/IMD ratio was significantly correlated with histologic grade, surgical stage, myometrial invasion, and extrauterine metastasis. There was a positive correlation between AQP1 expression and IMD and between AQP1/IMD ratio and VEGF expression. Conclusion AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis, and AQP1 level may be both a tumor indicator and a new therapeutic target.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18313673</pmid><doi>10.1016/j.ijgo.2007.12.006</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - blood supply Adenocarcinoma - metabolism Adult Antigens, CD34 - analysis Antigens, CD34 - immunology Aquaporin 1 - blood Aquaporin 1 - metabolism Aquaporin-1 Biological and medical sciences Carcinoma, Endometrioid - blood supply Carcinoma, Endometrioid - metabolism Carcinoma, Endometrioid - pathology Endometrial carcinoma Endometrial hyperplasia Endometrial Hyperplasia - immunology Endometrial Neoplasms - blood supply Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Medical Records Medical sciences Microcirculation - pathology Middle Aged Neovascularization, Pathologic - metabolism Obstetrics and Gynecology Pathogenesis Tumors Vascular Endothelial Growth Factors |
| title | Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria |
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