Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults

OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults. DESIGN: Descriptive cross‐sectional study. SETTING: General clinical research center. PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults. MEASUREMENTS: Subjects were monitored durin...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2008-05, Vol.56 (5), p.914-919
Main Authors: Carlson, Barbara W., Neelon, Virginia J., Carlson, John R., Hartman, Marilyn, Dogra, Sunil
Format: Article
Language:English
Subjects:
Adult
Age differences
Aged
Aged, 80 and over
aging
Aging - physiology
Biological and medical sciences
Blood tests
Brain - blood supply
Brain - physiology
brain hypoxia
Female
General aspects
Geriatrics
Humans
hypoxemia
Male
Medical sciences
Middle Aged
Miscellaneous
Older people
oximetry
Oxygen
Oxygen Consumption - physiology
Oxyhemoglobins - metabolism
Pneumology
Polysomnography
Public health. Hygiene
Public health. Hygiene-occupational medicine
Reference Values
Regional Blood Flow - physiology
Respiratory system : syndromes and miscellaneous diseases
Sleep
Sleep Stages - physiology
Spectroscopy, Near-Infrared
Wakefulness - physiology
Young adults
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Summary:OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults. DESIGN: Descriptive cross‐sectional study. SETTING: General clinical research center. PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults. MEASUREMENTS: Subjects were monitored during the first nightly sleep cycle using standard polysomnography, including measures of arterial oxyhemoglobin saturation (SaO2). Changes in regional cerebral oxyhemoglobin saturation (rcSO2) were used to estimate cerebral oxygen reserves. General linear models were used to test group differences in the change in SaO2 and rcSO2 during sleep. RESULTS: Older subjects had lower SaO2 than young subjects before sleep (baseline) (F(1,18)=5.1, P=.04) and during sleep (F(1,18)=10.7, P=.01). During sleep, half of the older subjects and none of the younger ones had SaO2 values below 95%. In addition, the older subjects had more periods of oxygen desaturation (drops in SaO2≥4%) (chi‐square=24.3, P=.01) and lower SaO2 levels during desaturation (F(1,18)=11.1, P
ISSN:0002-8614
1532-5415
DOI:10.1111/j.1532-5415.2008.01672.x