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Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults
OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults. DESIGN: Descriptive cross‐sectional study. SETTING: General clinical research center. PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults. MEASUREMENTS: Subjects were monitored durin...
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| Published in: | Journal of the American Geriatrics Society (JAGS) 2008-05, Vol.56 (5), p.914-919 |
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| creator | Carlson, Barbara W. Neelon, Virginia J. Carlson, John R. Hartman, Marilyn Dogra, Sunil |
| description | OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults.
DESIGN: Descriptive cross‐sectional study.
SETTING: General clinical research center.
PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults.
MEASUREMENTS: Subjects were monitored during the first nightly sleep cycle using standard polysomnography, including measures of arterial oxyhemoglobin saturation (SaO2). Changes in regional cerebral oxyhemoglobin saturation (rcSO2) were used to estimate cerebral oxygen reserves. General linear models were used to test group differences in the change in SaO2 and rcSO2 during sleep.
RESULTS: Older subjects had lower SaO2 than young subjects before sleep (baseline) (F(1,18)=5.1, P=.04) and during sleep (F(1,18)=10.7, P=.01). During sleep, half of the older subjects and none of the younger ones had SaO2 values below 95%. In addition, the older subjects had more periods of oxygen desaturation (drops in SaO2≥4%) (chi‐square=24.3, P=.01) and lower SaO2 levels during desaturation (F(1,18)=11.1, P |
| doi_str_mv | 10.1111/j.1532-5415.2008.01672.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69174960</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1473067071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5122-6af3a91535fc2c4f0ff06e6bf66c957ac24e03bb91f3c5b6575172ac0616a9ba3</originalsourceid><addsrcrecordid>eNqNkU-P0zAQxS0EYsvCV0AWEtwS_Cd2nAOHqrsUlhUVLAjBxXLccZXiJsVOIP32OLQqEicsWR7Jv_c08wYhTElO03m5zangLBMFFTkjROWEypLl4z00O3_cRzNCCMuUpMUFehTjlhDKiFIP0QVVXBVCqRnS1-Ped8H0XTjgeWv8ITYRdw4vIEAdjMer8bCBFn-ECOEnRHw1hKbd4DsPsMerNkKPmxav_BoCNu0af-2GdpPq-XrwfXyMHjjjIzw5vZfo8-vrT4s32e1q-XYxv82soIxl0jhuqtS7cJbZwhHniARZOyltJUpjWQGE13VFHbeilqIUtGTGEkmlqWrDL9GLo-8-dD8GiL3eNdGC96aFbohaVrQsKkkS-OwfcNsNIQ0eNaOEK1aKMkHqCNnQxRjA6X1odiYcNCV62oDe6iloPQWtpw3oPxvQY5I-PfkP9Q7Wf4WnyBPw_ASYaI13wbS2iWeOkeTLC5G4V0fuV-Ph8N8N6Jvl3VQlfXbUN7GH8aw34buWJS-F_vJ-me67mw8FL_Q3_hu0A6_2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>210382757</pqid></control><display><type>article</type><title>Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Carlson, Barbara W. ; Neelon, Virginia J. ; Carlson, John R. ; Hartman, Marilyn ; Dogra, Sunil</creator><creatorcontrib>Carlson, Barbara W. ; Neelon, Virginia J. ; Carlson, John R. ; Hartman, Marilyn ; Dogra, Sunil</creatorcontrib><description>OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults.
DESIGN: Descriptive cross‐sectional study.
SETTING: General clinical research center.
PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults.
MEASUREMENTS: Subjects were monitored during the first nightly sleep cycle using standard polysomnography, including measures of arterial oxyhemoglobin saturation (SaO2). Changes in regional cerebral oxyhemoglobin saturation (rcSO2) were used to estimate cerebral oxygen reserves. General linear models were used to test group differences in the change in SaO2 and rcSO2 during sleep.
RESULTS: Older subjects had lower SaO2 than young subjects before sleep (baseline) (F(1,18)=5.1, P=.04) and during sleep (F(1,18)=10.7, P=.01). During sleep, half of the older subjects and none of the younger ones had SaO2 values below 95%. In addition, the older subjects had more periods of oxygen desaturation (drops in SaO2≥4%) (chi‐square=24.3, P=.01) and lower SaO2 levels during desaturation (F(1,18)=11.1, P<.01). Although baseline values were similar, rcSO2 decreased during sleep 2.1% in older subjects (F(1,8)=3.8, P=.05) but increased 2.1% during sleep in younger subjects (F(1,9)=4.6, P=.04). When the older subjects awakened from sleep, rcSO2, but not SaO2, returned to baseline; both returned to baseline in younger subjects.
CONCLUSION: This exploratory analysis generated the hypothesis that lower SaO2, combined with declines in regional blood flow, contributes to decline in cerebral oxygen reserves during sleep in older subjects. Further study will assess the effects of factors (e.g., medical conditions, subclinical disorders, and sleep architecture) that might account for these differences.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2008.01672.x</identifier><identifier>PMID: 18384588</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Age differences ; Aged ; Aged, 80 and over ; aging ; Aging - physiology ; Biological and medical sciences ; Blood tests ; Brain - blood supply ; Brain - physiology ; brain hypoxia ; Female ; General aspects ; Geriatrics ; Humans ; hypoxemia ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Older people ; oximetry ; Oxygen ; Oxygen Consumption - physiology ; Oxyhemoglobins - metabolism ; Pneumology ; Polysomnography ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Reference Values ; Regional Blood Flow - physiology ; Respiratory system : syndromes and miscellaneous diseases ; Sleep ; Sleep Stages - physiology ; Spectroscopy, Near-Infrared ; Wakefulness - physiology ; Young adults</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2008-05, Vol.56 (5), p.914-919</ispartof><rights>2008, Copyright the Authors. Journal compilation © 2008, The American Geriatrics Society</rights><rights>2008 INIST-CNRS</rights><rights>Journal compilation 2008 The American Geriatrics Society/Blackwell Publishing</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5122-6af3a91535fc2c4f0ff06e6bf66c957ac24e03bb91f3c5b6575172ac0616a9ba3</citedby><cites>FETCH-LOGICAL-c5122-6af3a91535fc2c4f0ff06e6bf66c957ac24e03bb91f3c5b6575172ac0616a9ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20532345$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18384588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlson, Barbara W.</creatorcontrib><creatorcontrib>Neelon, Virginia J.</creatorcontrib><creatorcontrib>Carlson, John R.</creatorcontrib><creatorcontrib>Hartman, Marilyn</creatorcontrib><creatorcontrib>Dogra, Sunil</creatorcontrib><title>Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults.
DESIGN: Descriptive cross‐sectional study.
SETTING: General clinical research center.
PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults.
MEASUREMENTS: Subjects were monitored during the first nightly sleep cycle using standard polysomnography, including measures of arterial oxyhemoglobin saturation (SaO2). Changes in regional cerebral oxyhemoglobin saturation (rcSO2) were used to estimate cerebral oxygen reserves. General linear models were used to test group differences in the change in SaO2 and rcSO2 during sleep.
RESULTS: Older subjects had lower SaO2 than young subjects before sleep (baseline) (F(1,18)=5.1, P=.04) and during sleep (F(1,18)=10.7, P=.01). During sleep, half of the older subjects and none of the younger ones had SaO2 values below 95%. In addition, the older subjects had more periods of oxygen desaturation (drops in SaO2≥4%) (chi‐square=24.3, P=.01) and lower SaO2 levels during desaturation (F(1,18)=11.1, P<.01). Although baseline values were similar, rcSO2 decreased during sleep 2.1% in older subjects (F(1,8)=3.8, P=.05) but increased 2.1% during sleep in younger subjects (F(1,9)=4.6, P=.04). When the older subjects awakened from sleep, rcSO2, but not SaO2, returned to baseline; both returned to baseline in younger subjects.
CONCLUSION: This exploratory analysis generated the hypothesis that lower SaO2, combined with declines in regional blood flow, contributes to decline in cerebral oxygen reserves during sleep in older subjects. Further study will assess the effects of factors (e.g., medical conditions, subclinical disorders, and sleep architecture) that might account for these differences.</description><subject>Adult</subject><subject>Age differences</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aging</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood tests</subject><subject>Brain - blood supply</subject><subject>Brain - physiology</subject><subject>brain hypoxia</subject><subject>Female</subject><subject>General aspects</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>hypoxemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Older people</subject><subject>oximetry</subject><subject>Oxygen</subject><subject>Oxygen Consumption - physiology</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Pneumology</subject><subject>Polysomnography</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Reference Values</subject><subject>Regional Blood Flow - physiology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sleep</subject><subject>Sleep Stages - physiology</subject><subject>Spectroscopy, Near-Infrared</subject><subject>Wakefulness - physiology</subject><subject>Young adults</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkU-P0zAQxS0EYsvCV0AWEtwS_Cd2nAOHqrsUlhUVLAjBxXLccZXiJsVOIP32OLQqEicsWR7Jv_c08wYhTElO03m5zangLBMFFTkjROWEypLl4z00O3_cRzNCCMuUpMUFehTjlhDKiFIP0QVVXBVCqRnS1-Ped8H0XTjgeWv8ITYRdw4vIEAdjMer8bCBFn-ECOEnRHw1hKbd4DsPsMerNkKPmxav_BoCNu0af-2GdpPq-XrwfXyMHjjjIzw5vZfo8-vrT4s32e1q-XYxv82soIxl0jhuqtS7cJbZwhHniARZOyltJUpjWQGE13VFHbeilqIUtGTGEkmlqWrDL9GLo-8-dD8GiL3eNdGC96aFbohaVrQsKkkS-OwfcNsNIQ0eNaOEK1aKMkHqCNnQxRjA6X1odiYcNCV62oDe6iloPQWtpw3oPxvQY5I-PfkP9Q7Wf4WnyBPw_ASYaI13wbS2iWeOkeTLC5G4V0fuV-Ph8N8N6Jvl3VQlfXbUN7GH8aw34buWJS-F_vJ-me67mw8FL_Q3_hu0A6_2</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Carlson, Barbara W.</creator><creator>Neelon, Virginia J.</creator><creator>Carlson, John R.</creator><creator>Hartman, Marilyn</creator><creator>Dogra, Sunil</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults</title><author>Carlson, Barbara W. ; Neelon, Virginia J. ; Carlson, John R. ; Hartman, Marilyn ; Dogra, Sunil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5122-6af3a91535fc2c4f0ff06e6bf66c957ac24e03bb91f3c5b6575172ac0616a9ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age differences</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aging</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood tests</topic><topic>Brain - blood supply</topic><topic>Brain - physiology</topic><topic>brain hypoxia</topic><topic>Female</topic><topic>General aspects</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>hypoxemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Older people</topic><topic>oximetry</topic><topic>Oxygen</topic><topic>Oxygen Consumption - physiology</topic><topic>Oxyhemoglobins - metabolism</topic><topic>Pneumology</topic><topic>Polysomnography</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Reference Values</topic><topic>Regional Blood Flow - physiology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sleep</topic><topic>Sleep Stages - physiology</topic><topic>Spectroscopy, Near-Infrared</topic><topic>Wakefulness - physiology</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlson, Barbara W.</creatorcontrib><creatorcontrib>Neelon, Virginia J.</creatorcontrib><creatorcontrib>Carlson, John R.</creatorcontrib><creatorcontrib>Hartman, Marilyn</creatorcontrib><creatorcontrib>Dogra, Sunil</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlson, Barbara W.</au><au>Neelon, Virginia J.</au><au>Carlson, John R.</au><au>Hartman, Marilyn</au><au>Dogra, Sunil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2008-05</date><risdate>2008</risdate><volume>56</volume><issue>5</issue><spage>914</spage><epage>919</epage><pages>914-919</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults.
DESIGN: Descriptive cross‐sectional study.
SETTING: General clinical research center.
PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults.
MEASUREMENTS: Subjects were monitored during the first nightly sleep cycle using standard polysomnography, including measures of arterial oxyhemoglobin saturation (SaO2). Changes in regional cerebral oxyhemoglobin saturation (rcSO2) were used to estimate cerebral oxygen reserves. General linear models were used to test group differences in the change in SaO2 and rcSO2 during sleep.
RESULTS: Older subjects had lower SaO2 than young subjects before sleep (baseline) (F(1,18)=5.1, P=.04) and during sleep (F(1,18)=10.7, P=.01). During sleep, half of the older subjects and none of the younger ones had SaO2 values below 95%. In addition, the older subjects had more periods of oxygen desaturation (drops in SaO2≥4%) (chi‐square=24.3, P=.01) and lower SaO2 levels during desaturation (F(1,18)=11.1, P<.01). Although baseline values were similar, rcSO2 decreased during sleep 2.1% in older subjects (F(1,8)=3.8, P=.05) but increased 2.1% during sleep in younger subjects (F(1,9)=4.6, P=.04). When the older subjects awakened from sleep, rcSO2, but not SaO2, returned to baseline; both returned to baseline in younger subjects.
CONCLUSION: This exploratory analysis generated the hypothesis that lower SaO2, combined with declines in regional blood flow, contributes to decline in cerebral oxygen reserves during sleep in older subjects. Further study will assess the effects of factors (e.g., medical conditions, subclinical disorders, and sleep architecture) that might account for these differences.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18384588</pmid><doi>10.1111/j.1532-5415.2008.01672.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Age differences Aged Aged, 80 and over aging Aging - physiology Biological and medical sciences Blood tests Brain - blood supply Brain - physiology brain hypoxia Female General aspects Geriatrics Humans hypoxemia Male Medical sciences Middle Aged Miscellaneous Older people oximetry Oxygen Oxygen Consumption - physiology Oxyhemoglobins - metabolism Pneumology Polysomnography Public health. Hygiene Public health. Hygiene-occupational medicine Reference Values Regional Blood Flow - physiology Respiratory system : syndromes and miscellaneous diseases Sleep Sleep Stages - physiology Spectroscopy, Near-Infrared Wakefulness - physiology Young adults |
| title | Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults |
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