Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum

This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite c...

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Bibliographic Details
Published in:Experimental parasitology 2008-06, Vol.119 (2), p.301-303
Main Authors: Boxell, Annika, Lee, Stephanie Hui Chin, Jefferies, Ryan, Watt, Paul, Hopkins, Richard, Reid, Simon, Armson, Anthony, Ryan, Una
Format: Article
Language:English
Subjects:
Animals
Antimicrobial Cationic Peptides
Antiprotozoal Agents - administration & dosage
Biological and medical sciences
Cryptosporidium
Cryptosporidium parvum
Cryptosporidium parvum - metabolism
Delivery vehicle
Drug Carriers
Fluorescein - chemistry
Fundamental and applied biological sciences. Psychology
Insect Proteins
Life cycle. Host-agent relationship. Pathogenesis
Microscopy, Fluorescence
Peptides
Peptides - administration & dosage
Protozoa
Pyrrhocoricin
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Summary:This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2008.02.005