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Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum
This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite c...
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| Published in: | Experimental parasitology 2008-06, Vol.119 (2), p.301-303 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c424t-33193756782d803cf1f263111fd9ba75f399a37a652179e5e732bd04174e34883 |
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| cites | cdi_FETCH-LOGICAL-c424t-33193756782d803cf1f263111fd9ba75f399a37a652179e5e732bd04174e34883 |
| container_end_page | 303 |
| container_issue | 2 |
| container_start_page | 301 |
| container_title | Experimental parasitology |
| container_volume | 119 |
| creator | Boxell, Annika Lee, Stephanie Hui Chin Jefferies, Ryan Watt, Paul Hopkins, Richard Reid, Simon Armson, Anthony Ryan, Una |
| description | This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in
Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen. |
| doi_str_mv | 10.1016/j.exppara.2008.02.005 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0014-4894 |
| ispartof | Experimental parasitology, 2008-06, Vol.119 (2), p.301-303 |
| issn | 0014-4894 1090-2449 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals Antimicrobial Cationic Peptides Antiprotozoal Agents - administration & dosage Biological and medical sciences Cryptosporidium Cryptosporidium parvum Cryptosporidium parvum - metabolism Delivery vehicle Drug Carriers Fluorescein - chemistry Fundamental and applied biological sciences. Psychology Insect Proteins Life cycle. Host-agent relationship. Pathogenesis Microscopy, Fluorescence Peptides Peptides - administration & dosage Protozoa Pyrrhocoricin |
| title | Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum |
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