Notch and suppressor of Hairless regulate levels but not patterns of Delta expression in Drosophila

The Notch signal transduction pathway is highly conserved and governs many developmental decisions in metazoans. The ligand Delta, and its receptor Notch, are often expressed in complementary patterns during Drosophila postembryonic development. Notch signaling is thought to play a role in generatio...

Full description

Saved in:
Bibliographic Details
Published in:Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2008-05, Vol.46 (5), p.265-275
Main Authors: Parks, Annette L., Shalaby, Nevine A., Muskavitch, Marc A.T.
Format: Article
Language:English
Subjects:
Animals
Delta
Drosophila
Drosophila - genetics
Drosophila - growth & development
Drosophila Proteins - physiology
Eye - growth & development
Eye - metabolism
feedback regulation
Gene Expression Regulation, Developmental - physiology
Intracellular Signaling Peptides and Proteins
Membrane Proteins - biosynthesis
Membrane Proteins - genetics
Metazoa
Notch
Organ Specificity - genetics
Pupa - growth & development
Pupa - metabolism
Receptors, Notch - physiology
Repressor Proteins - physiology
signal transduction
Signal Transduction - genetics
Su(H)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Notch signal transduction pathway is highly conserved and governs many developmental decisions in metazoans. The ligand Delta, and its receptor Notch, are often expressed in complementary patterns during Drosophila postembryonic development. Notch signaling is thought to play a role in generation of these complementary patterns through feedback mechanisms that regulate Delta and Notch expression. We have examined Delta expression during postembryonic development, following global alteration of Notch‐dependent or Su(H)‐dependent transcriptional regulation. We find that Notch and Su(H) regulate Delta expression in a manner that varies by context. Surprisingly, we find that wild type Delta expression levels are influenced by Su(H)‐dependent mechanisms only in regions of high Delta/low Notch expression. In contrast, Delta expression levels in regions of low Delta/high Notch expression appear to be unaffected by Su(H)‐mediated regulation. We conclude that Notch pathway feedback regulation is unlikely to contribute to the generation of complementary patterns in the contexts examined. genesis 46:265–275, 2008. © 2008 Wiley‐Liss, Inc.
ISSN:1526-954X
1526-968X
DOI:10.1002/dvg.20391