Herba Artemisiae annuae tea preparation compared to sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria in adults: a randomized double-blind clinical trial

SUMMARY Tea preparations from the herb Artemisia annua L. (Aa) which is used in traditional Chinese medicine might offer an inexpensive way of producing artemisinin drugs locally. We compared Aa with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in semi-immune a...

Full description

Saved in:
Bibliographic Details
Published in:Tropical doctor 2008-04, Vol.38 (2), p.113-116
Main Authors: Blanke, Christoph H, Naisabha, Godson B, Balema, Mussa B, Mbaruku, Godfrey M, Heide, Lutz, Müller, Markus S
Format: Article
Language:English
Subjects:
Adult
Animals
Antimalarials - therapeutic use
Artemisia annua
Biological and medical sciences
Double-Blind Method
Drug Combinations
Drugs, Chinese Herbal - therapeutic use
Female
General aspects
Human protozoal diseases
Humans
Infectious diseases
Malaria
Malaria, Falciparum - drug therapy
Malaria, Falciparum - parasitology
Male
Medical sciences
Parasitemia - drug therapy
Parasitemia - parasitology
Parasitic diseases
Phytotherapy - methods
Plasmodium falciparum - drug effects
Protozoal diseases
Pyrimethamine - therapeutic use
Sulfadoxine - therapeutic use
Tanzania
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:SUMMARY Tea preparations from the herb Artemisia annua L. (Aa) which is used in traditional Chinese medicine might offer an inexpensive way of producing artemisinin drugs locally. We compared Aa with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in semi-immune adults. After seven days, the cure rate was 7/10 for the Aa compared to 7/9 for SP; this dropped to 4/10 for Aa and 4/9 for SP at day 14 and to 1/9 for Aa and 3/8 for SP at day 28.
ISSN:0049-4755
1758-1133
DOI:10.1258/td.2007.060184