RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder

We studied the association between RGS4 (rs951436) polymorphism and treatment response in electroconvulsive therapy (ECT) as well as risk of treatment-resistant depression. The study sample consisted of 119 patients with major depressive disorder (MDD) and 384 healthy control subjects. RGS4 polymorp...

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Bibliographic Details
Published in:Neuroscience letters 2008-05, Vol.437 (1), p.25-28
Main Authors: Huuhka, Kaija, Kampman, Olli, Anttila, Sami, Huuhka, Martti, Rontu, Riikka, Mattila, Kari M., Hurme, Mikko, Lehtimäki, Terho, Leinonen, Esa
Format: Article
Language:English
Subjects:
5' Untranslated Regions - genetics
Adult
Aged
Aged, 80 and over
Antidepressive Agents - therapeutic use
Biological and medical sciences
Depressive Disorder, Major - genetics
Depressive Disorder, Major - therapy
Drug Resistance
Electroconvulsive Therapy
Female
Fundamental and applied biological sciences. Psychology
Genotype
Humans
Major depression
Male
Middle Aged
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales
RGS Proteins - genetics
RGS4
Vertebrates: nervous system and sense organs
Young Adult
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Summary:We studied the association between RGS4 (rs951436) polymorphism and treatment response in electroconvulsive therapy (ECT) as well as risk of treatment-resistant depression. The study sample consisted of 119 patients with major depressive disorder (MDD) and 384 healthy control subjects. RGS4 polymorphism was not associated with treatment response in ECT or risk of MDD. According to the present data, the impact of RGS4 genotype is not decisive in major depressive disorder. The results provide preliminary data on the impact of RGS4 polymorphism in treatment response in ECT.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2008.03.065