Bacterial DNA as immune cell activator

Pattern recognition receptors of the innate and adaptive immune systems apparently recognize unmethylated CpG motifs of bacterial DNA. Cells of the innate immune system are activated directly by CpG motifs, and the resulting response dictates a Th1 bias to the developing adaptive immune response. In...

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Bibliographic Details
Published in:Trends in Microbiology 1998-12, Vol.6 (12), p.496-500
Main Authors: Lipford, Grayson B, Heeg, Klaus, Wagner, Hermann
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
antigen presenting cells
Antigen-Presenting Cells - immunology
Bacterial Vaccines - immunology
costimulation
CpG Islands
CpG ODN
cytokines
DNA, Bacterial - immunology
Humans
innate immunity
Oligodeoxyribonucleotides - immunology
pattern recognition molecules
Plasmids - immunology
Signal Transduction - immunology
Th1
Th1 Cells - immunology
Vaccines, DNA - immunology
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Summary:Pattern recognition receptors of the innate and adaptive immune systems apparently recognize unmethylated CpG motifs of bacterial DNA. Cells of the innate immune system are activated directly by CpG motifs, and the resulting response dictates a Th1 bias to the developing adaptive immune response. Interestingly, antigen receptor occupancy of cells of the adaptive immune system augments their responsiveness to CpG motifs, suggesting that co-stimulatory mechanisms are operative.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(98)01408-5