The legacy of lithium effects on development

The simple element lithium causes specific effects on early embryonic development. In amphibians, treatment during early cleavage enhances anterior and dorsal development at the expense of posterior and ventral development. Conversely, treatment at late cleavage reduces head development. While an ef...

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Bibliographic Details
Published in:Biology of the cell 1998-11, Vol.90 (8), p.585-589
Main Authors: Kao, Kenneth R, Elinson, Richard P
Format: Article
Language:English
Subjects:
amphibian
Amphibians - embryology
Animals
Cell Division - drug effects
development
Embryo, Nonmammalian - cytology
Embryo, Nonmammalian - drug effects
lithium
Lithium - pharmacology
Oocytes - cytology
Oocytes - drug effects
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Summary:The simple element lithium causes specific effects on early embryonic development. In amphibians, treatment during early cleavage enhances anterior and dorsal development at the expense of posterior and ventral development. Conversely, treatment at late cleavage reduces head development. While an effect of lithium on the phosphoinositide cycle was suspected, the enhancement of dorsoanterior development is now thought to result primarily from stimulation of the Wnt β - catenin pathway. The multiple uses of this pathway in development may account for lithium's various specific effects.
ISSN:0248-4900
1768-322X
DOI:10.1016/S0248-4900(99)80016-1