Is TGF-β important for the evolution of subcutaneuos chronic mycoses?

Summary Jorge Lobo’s and chromoblastomycosis are chronic deep mycosis that clinically manifests as keloid and verrucous polymorphic lesions of solid consistency and variable size that contain small scales and crusts. Few studies are available in the literature characterizing the in situ cellular and...

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Bibliographic Details
Published in:Medical hypotheses 2008-01, Vol.70 (6), p.1182-1185
Main Authors: Quaresma, Juarez Antonio Simões, de Oliveira, Euzébio, Cardoso de Brito, Arival
Format: Article
Language:English
Subjects:
Chronic Disease
Dermatomycoses - etiology
Dermatomycoses - microbiology
Dermatomycoses - pathology
Humans
Internal Medicine
Models, Immunological
Skin - microbiology
Skin - pathology
Soft Tissue Infections - etiology
Soft Tissue Infections - microbiology
Soft Tissue Infections - pathology
Subcutaneous Tissue - microbiology
Transforming Growth Factor beta - immunology
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Summary:Summary Jorge Lobo’s and chromoblastomycosis are chronic deep mycosis that clinically manifests as keloid and verrucous polymorphic lesions of solid consistency and variable size that contain small scales and crusts. Few studies are available in the literature characterizing the in situ cellular and humoral immune response, especially the involvement of cytokines which immunosuppressive and fibrogenic effects as the TGF-β. The hypothesis of the present paper is explaining the possible mechanism of this cytokine in cutaneous lesions pathology in chromoblastomycosis and lacaziosis (Jorge Lobo’s disease). The results of this investigation are a new hypothesis for ethiopatogenesis of these diseases: TGF-β is a double effect that follows fibrosis and immunosuppression in local skin.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2007.10.010