Early diagnosis followed by front-line autologous peripheral blood stem cell transplantation for patients affected by POEMS syndrome

Abstract The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes. This disease is progressive and weakening for patients and lead to death generally for neurological problem without therapy. We treated four patients affected by POEMS syndrome with front-line...

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Published in:Leukemia research 2008-08, Vol.32 (8), p.1309-1312
Main Authors: Laurenti, Luca, De Matteis, Silvia, Sabatelli, Mario, Conte, Amelia, Chiusolo, Patrizia, Sorà, Federica, Piccirillo, Nicola, Za, Tommaso, Tarnani, Michela, Rossi, Elena, Leone, Giuseppe, Sica, Simona
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Autologous peripheral blood stem cell transplantation
Early Diagnosis
Feasibility Studies
Female
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation
POEMS syndrome
POEMS Syndrome - therapy
Transplantation, Autologous
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Summary:Abstract The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes. This disease is progressive and weakening for patients and lead to death generally for neurological problem without therapy. We treated four patients affected by POEMS syndrome with front-line chemotherapy and autologous peripheral blood stem cell transplantation (aPBSCT). After a median follow-up of 40.5 months (range 12–52), all patients are alive with slow but progressive improvement in neurological disease, skin changes, performance status and without evidence of clonal plasmacytosis and organomegaly. In conclusion early diagnosis is crucial to obtain best response and improve clinical outcome.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2007.11.029