CDKN2A deletions in acute lymphoblastic leukemia of adolescents and young adults—An array CGH study

Abstract Deletion in chromosome 9p involving the CDKN2A locus (9p21.3) is known in many malignancies. To detect this deletion in adolescent ALL patients we used oligo array CGH and studied 54 patients aged 10–25 years. Deletion rate was 25/54 (46%), of these 19/25 (76%) were homozygous. Small deleti...

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Published in:Leukemia research 2008-08, Vol.32 (8), p.1228-1235
Main Authors: Usvasalo, Anu, Savola, Suvi, Räty, Riikka, Vettenranta, Kim, Harila-Saari, Arja, Koistinen, Pirjo, Savolainen, Eeva-Riitta, Elonen, Erkki, Saarinen-Pihkala, Ulla M, Knuutila, Sakari
Format: Article
Language:English
Subjects:
Adolescent
Adult
ALL
Array CGH
CDKN2A
Child
Copy number
Female
Genes, p16
Hematology, Oncology and Palliative Medicine
Humans
Male
Oligonucleotide Array Sequence Analysis - methods
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Prognosis
Sequence Deletion
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Summary:Abstract Deletion in chromosome 9p involving the CDKN2A locus (9p21.3) is known in many malignancies. To detect this deletion in adolescent ALL patients we used oligo array CGH and studied 54 patients aged 10–25 years. Deletion rate was 25/54 (46%), of these 19/25 (76%) were homozygous. Small deletions (
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2008.01.014