Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity

A series of 1,3,4-thiadiazol-2(3H)-ones (2a–j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds and in particular 2e, 2i and 2j exhibited an...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 1998-08, Vol.53 (8-9), p.586-589
Main Authors: Schenone, Silvia, Bruno, Olga, Ranise, Angelo, Bondavalli, Francesco, Filippelli, Walter, Falcone, Giuseppe, Piucci, Brunella, Sorrentino, Salvatore
Format: Article
Language:English
Subjects:
1,3,4-Thiadiazol-2(3H)-ones
Analgesics, Non-Narcotic - chemical synthesis
Analgesics, Non-Narcotic - chemistry
Analgesics, Non-Narcotic - pharmacology
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Rats
Substituted thiadiazolones
Thiadiazoles - chemical synthesis
Thiadiazoles - chemistry
Thiadiazoles - pharmacology
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Summary:A series of 1,3,4-thiadiazol-2(3H)-ones (2a–j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds and in particular 2e, 2i and 2j exhibited anti-inflammatory activity and were devoid of antipyretic properties.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(98)00073-1