Loading…
Major congenital malformations in United Arab Emirates (UAE): need for genetic counselling
Between January 1992 and January 1995 a total of 24233 babies born consecutively in Corniche Hospital which is the only maternity hospital in Abu Dhabi, the capital of UAE, were surveyed for the presence of major congenital malformations. A total of 401 infants (16.6/1000) had a major defect. Of the...
Saved in:
| Published in: | Annals of human genetics 1998-09, Vol.62 (5), p.411-418 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3591-542cb5ee6419d27c906bd5d1d43991df72b1019d818d84bb37433f1716ca93bd3 |
|---|---|
| cites | |
| container_end_page | 418 |
| container_issue | 5 |
| container_start_page | 411 |
| container_title | Annals of human genetics |
| container_volume | 62 |
| creator | AL TALABANI, J. SHUBBAR, A. I. MUSTAFA, K. E. |
| description | Between January 1992 and January 1995 a total of 24233 babies born
consecutively in Corniche
Hospital which is the only maternity hospital in Abu Dhabi, the capital
of UAE, were surveyed for
the presence of major congenital malformations. A total of 401 infants
(16.6/1000) had a major
defect. Of these malformations, 267 (67%) were associated with an estimated
recurrence risk greater
than 1%, and 95 (24%) carried an estimated recurrence risk greater than
10%. This included a total
of 91 cases of single gene disorders and 4 cases of cleft lip and palate
where a mother and another
sibling were affected putting their estimated recurrence risk in the high
category group. When
antenatal diagnosis is feasible, this should be considered in 60% of mothers
(a total of 242). In 59%
(a total of 237) the estimated recurrence risk was >1% and the antenatal
diagnosis of the disorder
was possible. The importance of Genetic Counselling is revealed in our
study since more than three
quarters of mothers were under 36 years old, and may well plan future pregnancies. |
| doi_str_mv | 10.1046/j.1469-1809.1998.6250411.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69186417</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1046_j_1469_1809_1998_6250411_x</cupid><sourcerecordid>69186417</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3591-542cb5ee6419d27c906bd5d1d43991df72b1019d818d84bb37433f1716ca93bd3</originalsourceid><addsrcrecordid>eNqVkE1r3DAQQEVpaTZJ_0IxpYT0YFdjybYUelnCJimk9JK99CL05UXGllPJpsm_j8yatscWBEIzb0YzD6EPgAvAtP7cFUBrngPDvADOWVGXFaYAxdMrtPmdeo02GGOSU4bxCTqNscMYSkbJW3QCGDOGCdugH99kN4ZMj_5gvZtknw2yb8cwyMmNPmbOZ_sUtybbBqmy3eCCnGzMLvfb3aerzNuUSXiWqu3kdGo0-2j73vnDOXrTyj7ad-t9hvY3u4fru_z---3X6-19rknFIa9oqVVlbU2Bm7LRHNfKVAYMJZyDaZtSAU4pBswwqhRpKCEtNFBryYky5AxdHPs-hvHnbOMkBhd1mkF6O85R1BxYat4k8OoI6jDGGGwrHoMbZHgWgMViVnRi0ScWfWIxK1az4ikVv19_mdVgzV-lR5UJ-LgCMurkMEivXfzD1YxWHCfs5oj9cr19_o8JxPbuNp30FksgNfqybiMHFZw5WNGNc_BJ9b_s8wIzyqfD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69186417</pqid></control><display><type>article</type><title>Major congenital malformations in United Arab Emirates (UAE): need for genetic counselling</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>AL TALABANI, J. ; SHUBBAR, A. I. ; MUSTAFA, K. E.</creator><creatorcontrib>AL TALABANI, J. ; SHUBBAR, A. I. ; MUSTAFA, K. E.</creatorcontrib><description>Between January 1992 and January 1995 a total of 24233 babies born
consecutively in Corniche
Hospital which is the only maternity hospital in Abu Dhabi, the capital
of UAE, were surveyed for
the presence of major congenital malformations. A total of 401 infants
(16.6/1000) had a major
defect. Of these malformations, 267 (67%) were associated with an estimated
recurrence risk greater
than 1%, and 95 (24%) carried an estimated recurrence risk greater than
10%. This included a total
of 91 cases of single gene disorders and 4 cases of cleft lip and palate
where a mother and another
sibling were affected putting their estimated recurrence risk in the high
category group. When
antenatal diagnosis is feasible, this should be considered in 60% of mothers
(a total of 242). In 59%
(a total of 237) the estimated recurrence risk was >1% and the antenatal
diagnosis of the disorder
was possible. The importance of Genetic Counselling is revealed in our
study since more than three
quarters of mothers were under 36 years old, and may well plan future pregnancies.</description><identifier>ISSN: 0003-4800</identifier><identifier>EISSN: 1469-1809</identifier><identifier>DOI: 10.1046/j.1469-1809.1998.6250411.x</identifier><identifier>PMID: 10088038</identifier><identifier>CODEN: ANHGAA</identifier><language>eng</language><publisher>Edinburgh, UK: Cambridge University Press</publisher><subject>Biological and medical sciences ; Congenital Abnormalities - epidemiology ; Congenital Abnormalities - genetics ; General aspects. Genetic counseling ; Genetic Counseling ; Health Education ; Humans ; Medical genetics ; Medical sciences ; Risk Factors ; United Arab Emirates - epidemiology</subject><ispartof>Annals of human genetics, 1998-09, Vol.62 (5), p.411-418</ispartof><rights>University College London 1998</rights><rights>1998 University College London</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3591-542cb5ee6419d27c906bd5d1d43991df72b1019d818d84bb37433f1716ca93bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1684590$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10088038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AL TALABANI, J.</creatorcontrib><creatorcontrib>SHUBBAR, A. I.</creatorcontrib><creatorcontrib>MUSTAFA, K. E.</creatorcontrib><title>Major congenital malformations in United Arab Emirates (UAE): need for genetic counselling</title><title>Annals of human genetics</title><addtitle>Ann. hum. genet</addtitle><description>Between January 1992 and January 1995 a total of 24233 babies born
consecutively in Corniche
Hospital which is the only maternity hospital in Abu Dhabi, the capital
of UAE, were surveyed for
the presence of major congenital malformations. A total of 401 infants
(16.6/1000) had a major
defect. Of these malformations, 267 (67%) were associated with an estimated
recurrence risk greater
than 1%, and 95 (24%) carried an estimated recurrence risk greater than
10%. This included a total
of 91 cases of single gene disorders and 4 cases of cleft lip and palate
where a mother and another
sibling were affected putting their estimated recurrence risk in the high
category group. When
antenatal diagnosis is feasible, this should be considered in 60% of mothers
(a total of 242). In 59%
(a total of 237) the estimated recurrence risk was >1% and the antenatal
diagnosis of the disorder
was possible. The importance of Genetic Counselling is revealed in our
study since more than three
quarters of mothers were under 36 years old, and may well plan future pregnancies.</description><subject>Biological and medical sciences</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Congenital Abnormalities - genetics</subject><subject>General aspects. Genetic counseling</subject><subject>Genetic Counseling</subject><subject>Health Education</subject><subject>Humans</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Risk Factors</subject><subject>United Arab Emirates - epidemiology</subject><issn>0003-4800</issn><issn>1469-1809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqVkE1r3DAQQEVpaTZJ_0IxpYT0YFdjybYUelnCJimk9JK99CL05UXGllPJpsm_j8yatscWBEIzb0YzD6EPgAvAtP7cFUBrngPDvADOWVGXFaYAxdMrtPmdeo02GGOSU4bxCTqNscMYSkbJW3QCGDOGCdugH99kN4ZMj_5gvZtknw2yb8cwyMmNPmbOZ_sUtybbBqmy3eCCnGzMLvfb3aerzNuUSXiWqu3kdGo0-2j73vnDOXrTyj7ad-t9hvY3u4fru_z---3X6-19rknFIa9oqVVlbU2Bm7LRHNfKVAYMJZyDaZtSAU4pBswwqhRpKCEtNFBryYky5AxdHPs-hvHnbOMkBhd1mkF6O85R1BxYat4k8OoI6jDGGGwrHoMbZHgWgMViVnRi0ScWfWIxK1az4ikVv19_mdVgzV-lR5UJ-LgCMurkMEivXfzD1YxWHCfs5oj9cr19_o8JxPbuNp30FksgNfqybiMHFZw5WNGNc_BJ9b_s8wIzyqfD</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>AL TALABANI, J.</creator><creator>SHUBBAR, A. I.</creator><creator>MUSTAFA, K. E.</creator><general>Cambridge University Press</general><general>Blackwell Science Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Major congenital malformations in United Arab Emirates (UAE): need for genetic counselling</title><author>AL TALABANI, J. ; SHUBBAR, A. I. ; MUSTAFA, K. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3591-542cb5ee6419d27c906bd5d1d43991df72b1019d818d84bb37433f1716ca93bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Congenital Abnormalities - genetics</topic><topic>General aspects. Genetic counseling</topic><topic>Genetic Counseling</topic><topic>Health Education</topic><topic>Humans</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Risk Factors</topic><topic>United Arab Emirates - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AL TALABANI, J.</creatorcontrib><creatorcontrib>SHUBBAR, A. I.</creatorcontrib><creatorcontrib>MUSTAFA, K. E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AL TALABANI, J.</au><au>SHUBBAR, A. I.</au><au>MUSTAFA, K. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major congenital malformations in United Arab Emirates (UAE): need for genetic counselling</atitle><jtitle>Annals of human genetics</jtitle><addtitle>Ann. hum. genet</addtitle><date>1998-09</date><risdate>1998</risdate><volume>62</volume><issue>5</issue><spage>411</spage><epage>418</epage><pages>411-418</pages><issn>0003-4800</issn><eissn>1469-1809</eissn><coden>ANHGAA</coden><abstract>Between January 1992 and January 1995 a total of 24233 babies born
consecutively in Corniche
Hospital which is the only maternity hospital in Abu Dhabi, the capital
of UAE, were surveyed for
the presence of major congenital malformations. A total of 401 infants
(16.6/1000) had a major
defect. Of these malformations, 267 (67%) were associated with an estimated
recurrence risk greater
than 1%, and 95 (24%) carried an estimated recurrence risk greater than
10%. This included a total
of 91 cases of single gene disorders and 4 cases of cleft lip and palate
where a mother and another
sibling were affected putting their estimated recurrence risk in the high
category group. When
antenatal diagnosis is feasible, this should be considered in 60% of mothers
(a total of 242). In 59%
(a total of 237) the estimated recurrence risk was >1% and the antenatal
diagnosis of the disorder
was possible. The importance of Genetic Counselling is revealed in our
study since more than three
quarters of mothers were under 36 years old, and may well plan future pregnancies.</abstract><cop>Edinburgh, UK</cop><pub>Cambridge University Press</pub><pmid>10088038</pmid><doi>10.1046/j.1469-1809.1998.6250411.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4800 |
| ispartof | Annals of human genetics, 1998-09, Vol.62 (5), p.411-418 |
| issn | 0003-4800 1469-1809 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69186417 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Biological and medical sciences Congenital Abnormalities - epidemiology Congenital Abnormalities - genetics General aspects. Genetic counseling Genetic Counseling Health Education Humans Medical genetics Medical sciences Risk Factors United Arab Emirates - epidemiology |
| title | Major congenital malformations in United Arab Emirates (UAE): need for genetic counselling |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A27%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Major%20congenital%20malformations%20in%20United%20Arab%20Emirates%20(UAE):%20need%20for%20genetic%20counselling&rft.jtitle=Annals%20of%20human%20genetics&rft.au=AL%20TALABANI,%20J.&rft.date=1998-09&rft.volume=62&rft.issue=5&rft.spage=411&rft.epage=418&rft.pages=411-418&rft.issn=0003-4800&rft.eissn=1469-1809&rft.coden=ANHGAA&rft_id=info:doi/10.1046/j.1469-1809.1998.6250411.x&rft_dat=%3Cproquest_cross%3E69186417%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3591-542cb5ee6419d27c906bd5d1d43991df72b1019d818d84bb37433f1716ca93bd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69186417&rft_id=info:pmid/10088038&rft_cupid=10_1046_j_1469_1809_1998_6250411_x&rfr_iscdi=true |