Comparative Effects of a Fixed Combination of Reproterol Hydrochloride and Disodium Cromoglycate with Each Agent Alone on Antigen-Induced Airway Responses in Sheep

• Published in: Pulmonary pharmacology & therapeutics 1998-08, Vol.11 (4), p.271-276
• Main Authors: Abraham, W.M., Sabater, J.R., Szelenyi, S., Bähre, M.
• Format: Article
• Language: English
• Subjects: Administration, Inhalation; Adrenergic beta-Agonists - pharmacology; Adrenergic beta-Agonists - therapeutic use; Aerosols; Airway Resistance - drug effects; Animals; Anti-Allergic Agents - pharmacology; Anti-Allergic Agents - therapeutic use; Area Under Curve; Asthma - drug therapy; Asthma - physiopathology; Asthma, Therapy, Allergen challenge, Airway hyperresponsiveness, Late phase response; Bronchial Hyperreactivity - physiopathology; Bronchial Hyperreactivity - prevention & control; Bronchial Provocation Tests; Bronchodilator Agents - pharmacology; Bronchodilator Agents - therapeutic use; Cromolyn Sodium - pharmacology; Cromolyn Sodium - therapeutic use; Drug Combinations; Drug Therapy, Combination; Metaproterenol - analogs & derivatives; Metaproterenol - pharmacology; Metaproterenol - therapeutic use; Random Allocation; Sheep; Theophylline - analogs & derivatives; Theophylline - pharmacology; Theophylline - therapeutic use
• ISSN: 1094-5539; 1522-9629
• DOI: 10.1006/pupt.1998.0150

The purpose of this study was to compare the effectiveness of an eight day treatment with clinically relevant doses of a fixed combination of theβ2mimetic reproterol hydrochloride and disodium cromoglycate with each agent given alone against antigen-induced early (EAR) and late airway responses (LAR) as well as post-antigen-induced airway hyperresponsiveness (AHR) in allergic sheep. Animals were treated in a randomized fashion with either the inhaled combination (n=6), reproterol hydrochloride alone (n=6), disodium cromoglycate alone (n=6), or placebo (n=8). Treatments (two puffs from a metered dose inhaler) were given three times a day for 7 days and once on the 8th day 1 h before airway challenge withAscaris suumantigen. In the placebo trial, antigen challenge resulted in EAR and LAR as measured by increases in specific lung resistance; these changes were followed 24 h later by AHR to inhaled carbachol. With respect to the placebo trial, treatment with reproterol hydrochloride reduced the EAR (P