Loading…
Comparative Effects of a Fixed Combination of Reproterol Hydrochloride and Disodium Cromoglycate with Each Agent Alone on Antigen-Induced Airway Responses in Sheep
The purpose of this study was to compare the effectiveness of an eight day treatment with clinically relevant doses of a fixed combination of theβ2mimetic reproterol hydrochloride and disodium cromoglycate with each agent given alone against antigen-induced early (EAR) and late airway responses (LAR...
Saved in:
| Published in: | Pulmonary pharmacology & therapeutics 1998-08, Vol.11 (4), p.271-276 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 276 |
| container_issue | 4 |
| container_start_page | 271 |
| container_title | Pulmonary pharmacology & therapeutics |
| container_volume | 11 |
| creator | Abraham, W.M. Sabater, J.R. Szelenyi, S. Bähre, M. |
| description | The purpose of this study was to compare the effectiveness of an eight day treatment with clinically relevant doses of a fixed combination of theβ2mimetic reproterol hydrochloride and disodium cromoglycate with each agent given alone against antigen-induced early (EAR) and late airway responses (LAR) as well as post-antigen-induced airway hyperresponsiveness (AHR) in allergic sheep. Animals were treated in a randomized fashion with either the inhaled combination (n=6), reproterol hydrochloride alone (n=6), disodium cromoglycate alone (n=6), or placebo (n=8). Treatments (two puffs from a metered dose inhaler) were given three times a day for 7 days and once on the 8th day 1 h before airway challenge withAscaris suumantigen. In the placebo trial, antigen challenge resulted in EAR and LAR as measured by increases in specific lung resistance; these changes were followed 24 h later by AHR to inhaled carbachol. With respect to the placebo trial, treatment with reproterol hydrochloride reduced the EAR (P |
| doi_str_mv | 10.1006/pupt.1998.0150 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69190410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S109455399890150X</els_id><sourcerecordid>69190410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c335t-a8b4017aeb94729306282887a909831eae54163e8454c03e5f7ab559020154883</originalsourceid><addsrcrecordid>eNp1kU1v3CAQhlGVqknTXnuMOOXmLRjwwtHabppIkSr144wwHmepbHAAJ9nf0z9arM2hl4rDjGZe3tHMg9AnSjaUkObzvMx5Q5WSG0IFeYMuqKjrSjW1Ois5UbwSgqlz9D6l34SQLWfiHTqnpLySX6A_uzDNJprsngDvhwFsTjgM2OAb9wI9Lu3O-dIOfi1_hzmGDDGM-PbYx2APY4iuB2x8j7-4FHq3THgXwxQexqM1GfCzywe8N_aA2wfwGbdj8ICLXeuzK5XqzveLLaNaF5_NsYxIc_AJEnYe_zgAzB_Q28GMCT6-xkv062b_c3db3X_7erdr7yvLmMiVkR0vWxnoFN_WipGmlrWUW6OIkoyCAcFpw0BywS1hIIat6YRQpC6n41KyS3R98i07Pi6Qsp5csjCOxkNYkm4UVYRTUoSbk9DGkFKEQc_RTSYeNSV6xaJXLHrFolcs5cPVq_PSTdD_Iz9xKAJ5EkDZ78lB1Mk68OUsLhYkug_uf95_AWjnnV0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69190410</pqid></control><display><type>article</type><title>Comparative Effects of a Fixed Combination of Reproterol Hydrochloride and Disodium Cromoglycate with Each Agent Alone on Antigen-Induced Airway Responses in Sheep</title><source>Elsevier</source><creator>Abraham, W.M. ; Sabater, J.R. ; Szelenyi, S. ; Bähre, M.</creator><creatorcontrib>Abraham, W.M. ; Sabater, J.R. ; Szelenyi, S. ; Bähre, M.</creatorcontrib><description><![CDATA[The purpose of this study was to compare the effectiveness of an eight day treatment with clinically relevant doses of a fixed combination of theβ2mimetic reproterol hydrochloride and disodium cromoglycate with each agent given alone against antigen-induced early (EAR) and late airway responses (LAR) as well as post-antigen-induced airway hyperresponsiveness (AHR) in allergic sheep. Animals were treated in a randomized fashion with either the inhaled combination (n=6), reproterol hydrochloride alone (n=6), disodium cromoglycate alone (n=6), or placebo (n=8). Treatments (two puffs from a metered dose inhaler) were given three times a day for 7 days and once on the 8th day 1 h before airway challenge withAscaris suumantigen. In the placebo trial, antigen challenge resulted in EAR and LAR as measured by increases in specific lung resistance; these changes were followed 24 h later by AHR to inhaled carbachol. With respect to the placebo trial, treatment with reproterol hydrochloride reduced the EAR (P<0.05) and blocked the LAR (P<0.05), but had no effect on the post-challenge AHR. Treatment with disodium cromoglycate also reduced the EAR (P<0.05), blocked the LAR (P<0.05), and blocked the post-antigen-induced AHR (P<0.05). Treatment with the fixed combination reduced the EAR (P<0.05), blocked the LAR (P<0.05), and blocked the post-antigen-induced AHR (P<0.05). Comparison of the different agents indicated that the fixed combination gave significantly increased protection against the EAR than either agent alone, gave slightly better (P<0.05) protection against the late response than cromolyn sodium and gave better protection against post-antigen-induced AHR than reproterol hydrochloride alone. These results suggest that a fixed combination of aβ2-mimetic and disodium cromoglycate provides some increased protection against antigen-induced airway responses when compared to either agent alone in a controlled laboratory setting.]]></description><identifier>ISSN: 1094-5539</identifier><identifier>EISSN: 1522-9629</identifier><identifier>DOI: 10.1006/pupt.1998.0150</identifier><identifier>PMID: 10101743</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Inhalation ; Adrenergic beta-Agonists - pharmacology ; Adrenergic beta-Agonists - therapeutic use ; Aerosols ; Airway Resistance - drug effects ; Animals ; Anti-Allergic Agents - pharmacology ; Anti-Allergic Agents - therapeutic use ; Area Under Curve ; Asthma - drug therapy ; Asthma - physiopathology ; Asthma, Therapy, Allergen challenge, Airway hyperresponsiveness, Late phase response ; Bronchial Hyperreactivity - physiopathology ; Bronchial Hyperreactivity - prevention & control ; Bronchial Provocation Tests ; Bronchodilator Agents - pharmacology ; Bronchodilator Agents - therapeutic use ; Cromolyn Sodium - pharmacology ; Cromolyn Sodium - therapeutic use ; Drug Combinations ; Drug Therapy, Combination ; Metaproterenol - analogs & derivatives ; Metaproterenol - pharmacology ; Metaproterenol - therapeutic use ; Random Allocation ; Sheep ; Theophylline - analogs & derivatives ; Theophylline - pharmacology ; Theophylline - therapeutic use</subject><ispartof>Pulmonary pharmacology & therapeutics, 1998-08, Vol.11 (4), p.271-276</ispartof><rights>1998 Academic Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10101743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abraham, W.M.</creatorcontrib><creatorcontrib>Sabater, J.R.</creatorcontrib><creatorcontrib>Szelenyi, S.</creatorcontrib><creatorcontrib>Bähre, M.</creatorcontrib><title>Comparative Effects of a Fixed Combination of Reproterol Hydrochloride and Disodium Cromoglycate with Each Agent Alone on Antigen-Induced Airway Responses in Sheep</title><title>Pulmonary pharmacology & therapeutics</title><addtitle>Pulm Pharmacol Ther</addtitle><description><![CDATA[The purpose of this study was to compare the effectiveness of an eight day treatment with clinically relevant doses of a fixed combination of theβ2mimetic reproterol hydrochloride and disodium cromoglycate with each agent given alone against antigen-induced early (EAR) and late airway responses (LAR) as well as post-antigen-induced airway hyperresponsiveness (AHR) in allergic sheep. Animals were treated in a randomized fashion with either the inhaled combination (n=6), reproterol hydrochloride alone (n=6), disodium cromoglycate alone (n=6), or placebo (n=8). Treatments (two puffs from a metered dose inhaler) were given three times a day for 7 days and once on the 8th day 1 h before airway challenge withAscaris suumantigen. In the placebo trial, antigen challenge resulted in EAR and LAR as measured by increases in specific lung resistance; these changes were followed 24 h later by AHR to inhaled carbachol. With respect to the placebo trial, treatment with reproterol hydrochloride reduced the EAR (P<0.05) and blocked the LAR (P<0.05), but had no effect on the post-challenge AHR. Treatment with disodium cromoglycate also reduced the EAR (P<0.05), blocked the LAR (P<0.05), and blocked the post-antigen-induced AHR (P<0.05). Treatment with the fixed combination reduced the EAR (P<0.05), blocked the LAR (P<0.05), and blocked the post-antigen-induced AHR (P<0.05). Comparison of the different agents indicated that the fixed combination gave significantly increased protection against the EAR than either agent alone, gave slightly better (P<0.05) protection against the late response than cromolyn sodium and gave better protection against post-antigen-induced AHR than reproterol hydrochloride alone. These results suggest that a fixed combination of aβ2-mimetic and disodium cromoglycate provides some increased protection against antigen-induced airway responses when compared to either agent alone in a controlled laboratory setting.]]></description><subject>Administration, Inhalation</subject><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Adrenergic beta-Agonists - therapeutic use</subject><subject>Aerosols</subject><subject>Airway Resistance - drug effects</subject><subject>Animals</subject><subject>Anti-Allergic Agents - pharmacology</subject><subject>Anti-Allergic Agents - therapeutic use</subject><subject>Area Under Curve</subject><subject>Asthma - drug therapy</subject><subject>Asthma - physiopathology</subject><subject>Asthma, Therapy, Allergen challenge, Airway hyperresponsiveness, Late phase response</subject><subject>Bronchial Hyperreactivity - physiopathology</subject><subject>Bronchial Hyperreactivity - prevention & control</subject><subject>Bronchial Provocation Tests</subject><subject>Bronchodilator Agents - pharmacology</subject><subject>Bronchodilator Agents - therapeutic use</subject><subject>Cromolyn Sodium - pharmacology</subject><subject>Cromolyn Sodium - therapeutic use</subject><subject>Drug Combinations</subject><subject>Drug Therapy, Combination</subject><subject>Metaproterenol - analogs & derivatives</subject><subject>Metaproterenol - pharmacology</subject><subject>Metaproterenol - therapeutic use</subject><subject>Random Allocation</subject><subject>Sheep</subject><subject>Theophylline - analogs & derivatives</subject><subject>Theophylline - pharmacology</subject><subject>Theophylline - therapeutic use</subject><issn>1094-5539</issn><issn>1522-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v3CAQhlGVqknTXnuMOOXmLRjwwtHabppIkSr144wwHmepbHAAJ9nf0z9arM2hl4rDjGZe3tHMg9AnSjaUkObzvMx5Q5WSG0IFeYMuqKjrSjW1Ois5UbwSgqlz9D6l34SQLWfiHTqnpLySX6A_uzDNJprsngDvhwFsTjgM2OAb9wI9Lu3O-dIOfi1_hzmGDDGM-PbYx2APY4iuB2x8j7-4FHq3THgXwxQexqM1GfCzywe8N_aA2wfwGbdj8ICLXeuzK5XqzveLLaNaF5_NsYxIc_AJEnYe_zgAzB_Q28GMCT6-xkv062b_c3db3X_7erdr7yvLmMiVkR0vWxnoFN_WipGmlrWUW6OIkoyCAcFpw0BywS1hIIat6YRQpC6n41KyS3R98i07Pi6Qsp5csjCOxkNYkm4UVYRTUoSbk9DGkFKEQc_RTSYeNSV6xaJXLHrFolcs5cPVq_PSTdD_Iz9xKAJ5EkDZ78lB1Mk68OUsLhYkug_uf95_AWjnnV0</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Abraham, W.M.</creator><creator>Sabater, J.R.</creator><creator>Szelenyi, S.</creator><creator>Bähre, M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Comparative Effects of a Fixed Combination of Reproterol Hydrochloride and Disodium Cromoglycate with Each Agent Alone on Antigen-Induced Airway Responses in Sheep</title><author>Abraham, W.M. ; Sabater, J.R. ; Szelenyi, S. ; Bähre, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-a8b4017aeb94729306282887a909831eae54163e8454c03e5f7ab559020154883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Inhalation</topic><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Adrenergic beta-Agonists - therapeutic use</topic><topic>Aerosols</topic><topic>Airway Resistance - drug effects</topic><topic>Animals</topic><topic>Anti-Allergic Agents - pharmacology</topic><topic>Anti-Allergic Agents - therapeutic use</topic><topic>Area Under Curve</topic><topic>Asthma - drug therapy</topic><topic>Asthma - physiopathology</topic><topic>Asthma, Therapy, Allergen challenge, Airway hyperresponsiveness, Late phase response</topic><topic>Bronchial Hyperreactivity - physiopathology</topic><topic>Bronchial Hyperreactivity - prevention & control</topic><topic>Bronchial Provocation Tests</topic><topic>Bronchodilator Agents - pharmacology</topic><topic>Bronchodilator Agents - therapeutic use</topic><topic>Cromolyn Sodium - pharmacology</topic><topic>Cromolyn Sodium - therapeutic use</topic><topic>Drug Combinations</topic><topic>Drug Therapy, Combination</topic><topic>Metaproterenol - analogs & derivatives</topic><topic>Metaproterenol - pharmacology</topic><topic>Metaproterenol - therapeutic use</topic><topic>Random Allocation</topic><topic>Sheep</topic><topic>Theophylline - analogs & derivatives</topic><topic>Theophylline - pharmacology</topic><topic>Theophylline - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abraham, W.M.</creatorcontrib><creatorcontrib>Sabater, J.R.</creatorcontrib><creatorcontrib>Szelenyi, S.</creatorcontrib><creatorcontrib>Bähre, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pulmonary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abraham, W.M.</au><au>Sabater, J.R.</au><au>Szelenyi, S.</au><au>Bähre, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Effects of a Fixed Combination of Reproterol Hydrochloride and Disodium Cromoglycate with Each Agent Alone on Antigen-Induced Airway Responses in Sheep</atitle><jtitle>Pulmonary pharmacology & therapeutics</jtitle><addtitle>Pulm Pharmacol Ther</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>11</volume><issue>4</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>1094-5539</issn><eissn>1522-9629</eissn><abstract><![CDATA[The purpose of this study was to compare the effectiveness of an eight day treatment with clinically relevant doses of a fixed combination of theβ2mimetic reproterol hydrochloride and disodium cromoglycate with each agent given alone against antigen-induced early (EAR) and late airway responses (LAR) as well as post-antigen-induced airway hyperresponsiveness (AHR) in allergic sheep. Animals were treated in a randomized fashion with either the inhaled combination (n=6), reproterol hydrochloride alone (n=6), disodium cromoglycate alone (n=6), or placebo (n=8). Treatments (two puffs from a metered dose inhaler) were given three times a day for 7 days and once on the 8th day 1 h before airway challenge withAscaris suumantigen. In the placebo trial, antigen challenge resulted in EAR and LAR as measured by increases in specific lung resistance; these changes were followed 24 h later by AHR to inhaled carbachol. With respect to the placebo trial, treatment with reproterol hydrochloride reduced the EAR (P<0.05) and blocked the LAR (P<0.05), but had no effect on the post-challenge AHR. Treatment with disodium cromoglycate also reduced the EAR (P<0.05), blocked the LAR (P<0.05), and blocked the post-antigen-induced AHR (P<0.05). Treatment with the fixed combination reduced the EAR (P<0.05), blocked the LAR (P<0.05), and blocked the post-antigen-induced AHR (P<0.05). Comparison of the different agents indicated that the fixed combination gave significantly increased protection against the EAR than either agent alone, gave slightly better (P<0.05) protection against the late response than cromolyn sodium and gave better protection against post-antigen-induced AHR than reproterol hydrochloride alone. These results suggest that a fixed combination of aβ2-mimetic and disodium cromoglycate provides some increased protection against antigen-induced airway responses when compared to either agent alone in a controlled laboratory setting.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>10101743</pmid><doi>10.1006/pupt.1998.0150</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1094-5539 |
| ispartof | Pulmonary pharmacology & therapeutics, 1998-08, Vol.11 (4), p.271-276 |
| issn | 1094-5539 1522-9629 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69190410 |
| source | Elsevier |
| subjects | Administration, Inhalation Adrenergic beta-Agonists - pharmacology Adrenergic beta-Agonists - therapeutic use Aerosols Airway Resistance - drug effects Animals Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use Area Under Curve Asthma - drug therapy Asthma - physiopathology Asthma, Therapy, Allergen challenge, Airway hyperresponsiveness, Late phase response Bronchial Hyperreactivity - physiopathology Bronchial Hyperreactivity - prevention & control Bronchial Provocation Tests Bronchodilator Agents - pharmacology Bronchodilator Agents - therapeutic use Cromolyn Sodium - pharmacology Cromolyn Sodium - therapeutic use Drug Combinations Drug Therapy, Combination Metaproterenol - analogs & derivatives Metaproterenol - pharmacology Metaproterenol - therapeutic use Random Allocation Sheep Theophylline - analogs & derivatives Theophylline - pharmacology Theophylline - therapeutic use |
| title | Comparative Effects of a Fixed Combination of Reproterol Hydrochloride and Disodium Cromoglycate with Each Agent Alone on Antigen-Induced Airway Responses in Sheep |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T16%3A54%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20Effects%20of%20a%20Fixed%20Combination%20of%20Reproterol%20Hydrochloride%20and%20Disodium%20Cromoglycate%20with%20Each%20Agent%20Alone%20on%20Antigen-Induced%20Airway%20Responses%20in%20Sheep&rft.jtitle=Pulmonary%20pharmacology%20&%20therapeutics&rft.au=Abraham,%20W.M.&rft.date=1998-08-01&rft.volume=11&rft.issue=4&rft.spage=271&rft.epage=276&rft.pages=271-276&rft.issn=1094-5539&rft.eissn=1522-9629&rft_id=info:doi/10.1006/pupt.1998.0150&rft_dat=%3Cproquest_cross%3E69190410%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c335t-a8b4017aeb94729306282887a909831eae54163e8454c03e5f7ab559020154883%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69190410&rft_id=info:pmid/10101743&rfr_iscdi=true |